Purpose: We aimed to disclose the impact of the pandemic on breast cancer patients in a specialized breast cancer center (BCC). Methods: A total of 501 breast cancer patients with a first appointment in the BCC from April 1st, 2019 to March 31st, 2021 were divided into four consecutive periods of 6 months. Data from the homologous semesters was compared. Patients with an appointment in the BCC during the study ...
Objective: To describe the clinical, biochemical, and genetic features of both new and previously reported patients with congenital disorders of glycosylation (CDGs) diagnosed in Portugal over the last 20 years. Study design: The cohort includes patients with an unexplained multisystem or single organ involvement, with or without psychomotor disability. Serum sialotransferrin isoforms and, whenever necessary, a...
The deep-sea constitutes a true unexplored frontier and a potential source of innovative drug scaffolds. Here, we present the genome sequence of two novel marine actinobacterial strains, MA3_2.13 and S07_1.15, isolated from deep-sea samples (sediments and sponge) and collected at Madeira archipelago (NE Atlantic Ocean; Portugal). The de novo assembly of both genomes was achieved using a hybrid strategy that com...
Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason for tumor relapse, metastasis and therapy resistance, leading to poor overall survival. Thus, the elimination of CSCs became a crucial goal for cancer treatment. The identification of these cells has been performed by using cell-surfac...
Botulinum toxin type A has been approved for spasticity management in poststroke patients. The adverse effects are generally of two types: those related to local injection; and those related to the systemic effects from spread of the toxin. Contralateral weakness after botulinum toxin A treatment is a rarely reported adverse effect. We report the case of a 33-year-old female who had been receiving regular injec...
Quadriceps tendon rupture is a rare lesion, occurring most frequently in males over 60 years following a fall or trauma and associated with systemic diseases and risk factors. Bilateral injury is even more uncommon and disabling. The authors report a case of spontaneous bilateral quadriceps tendon rupture, non-simultaneous (8 days apart), in a healthy 54-year-old Black male mason, that may be work-related. The ...
Composite material usage in aircraft has been rising since the 1990s, with significant increases in manufacturing productivity and repeatability due to automation in the production of aeronautic parts made of composite materials, becoming a strong driver for widespread adoption of composites in this industry. Automated Tape Layup (ATL) and Automated Fibre Placement (AFP) are two of the most important automated ...
Introdução: A doença de Dupuytren é uma patologia proliferativa benigna do tecido conjuntivo que envolve a fáscia palmar. A primeira manifestação clínica reportada pelo doente é o espessamento da pele junto à articulação MCF. O 5º dedo é o mais afetado, e a doença de Dupuytren atinge mais frequentemente homens com mais de 40 anos. A diabetes mellitus, a dependência do álcool e do tabaco e o VIH estão associados...