As alterações climáticas causam impactes globais, mas têm particular incidência nas áreas urbanas. As soluções baseadas na natureza (SbN) emergem como alternativas importantes, aproveitando os processos naturais. Na Europa, as SbN são utilizadas principalmente nos ambientes urbanos para aumentar a resiliência a fenómenos climático-meteorológicos extremos, num contexto de alterações climáticas. A União Europeia ...
Currently, there are no lung ultrasound (LUS) established guidelines for the identification of B-lines. This study aimed to evaluate if the US settings have an impact on the number of B-lines in invasively ventilated patients.
Increasing end-of-life material recovery and its application in new products is essential to reduce resource consumption. This paper assesses the cradle-to-gate life cycle energy and carbon dioxide (CO2) emissions of a new road safety barrier product to be installed around guardrails’ poles. To analyze the potential life cycle benefit of incorporating recycled materials, a base case product A, produced with con...
Additive manufacturing has the potential to make a longstanding impact on the manufacturing world and is a core element of the Fourth Industrial Revolution. Additive manufacturing signifies a new disruptive path on how we will produce parts and products. Several studies suggest this technology could foster sustainability into manufacturing systems based on its potential of optimizing material consumption, creat...
Natural compounds have had increasing applications in the biotechnological sector, with a large fraction of these substances being channeled to the pharmaceutical industry due to their important pharmacological properties. The discovery of new bioactive molecules with novel mechanisms of action constitutes a promising solution for the design of alternative therapeutic solutions. Actinobacteria are a large group...
In recent decades, harmful cyanobacterial blooms (HCBs) have become a severe hazard for human health mainly in drinking water resources and are responsible for serious ecological disturbances in freshwater ecosystems. The present study aims to explore the potential of actinobacteria isolated from sediment samples collected from Moroccan salt river to control HCBs mainly through Microcystis aeruginosa lysis. In ...
In Portugal, the potent paralytic shellfish toxins (PSTs) have appeared irregularly since the onset of a national monitoring program for marine biotoxins in 1986. In years where high contamination levels were attained in bivalves, sporadic cases of human poisonings have been recorded, as in 1994 and 2007. The reappearance of high contamination levels led to the appearance of new cases during the autumn of 2018....
Unlike most lysosomal proteins, β-glucocerebrosidase (GCase), the hydrolase defective in Gaucher disease (GD), is delivered to lysosomes through its interaction with the transmembrane protein LIMP2. A few years ago, mutations in its coding gene, SCARB2, were reported to modify the severity of GD phenotype. The existence of a great variety of GD phenotypes is well-known, with numerous patients who carry identica...
Background: Genetic heterogeneity and compound heterozygosis give rise to a continuous spectrum of phenylalanine hydroxylase deficiency and metabolic phenotypes in phenylketonuria (PKU). The most used parameters for evaluating phenotype in PKU are pretreatment phenylalanine (Phe) levels, tolerance for dietary Phe, and Phe overloading test. Phenotype can vary from a "classic" (severe) form to mild hyperphenylala...
The concern for the environment begun to emerge in a more intriguing way in 1960 ́s, and since then a long journey of reflections about the origin and mitigation of atrocities committed by the human being has triggered ecological movements, laws and higher education graduations. However, the root of all environmental barbarism lies on the human being crises and his distorted, corrupted values. Nowadays, the con...