51 documents found, page 1 of 6
Selective modulation of epileptic tissue by an adenosine A3 receptor‐activating...
Ghosh, Anwesha; Ribeiro Rodrigues, Leonor; Ruffolo, Gabriele; Alfano, Veronica; Domingos, Cátia; Rei, Nádia; Tosh, Dilip K.; Rombo, Diogo M.Background and purpose: Adenosine, through the A1 receptor (A1R), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure medications has been hampered by their cardiac side effects. A moderately A1R-selective agonist, MRS5474, has been reported to suppress seizures without considerable cardiac action. Hypothesizing that this drug could act through other than A1R and/or th...
Adjusting the brakes to adjust neuronal activity: adenosinergic modulation of G...
Sebastião, Ana M; Ribeiro, Joaquim A.About 50 years elapsed from the publication of the first full paper on the neuromodulatory action of adenosine at a 'simple' synapse model, the neuromuscular junction (Ginsborg and Hirst, 1972). In that study adenosine was used as a tool to increase cyclic AMP and for the great surprise, it decreased rather than increased neurotransmitter release, and for a further surprise, its action was prevented by theophyl...
Changes in adenosine receptors and neurotrophic factors in the SOD1G93A mouse m...
Rei, Nádia; Valente, Cláudia A.; Vaz, Sandra H.; Farinha-Ferreira, Miguel; Ribeiro, Joaquim A.; Sebastião, Ana M.Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of corticospinal tract motor neurons. Previous studies showed that adenosine-mediated neuromodulation is disturbed in ALS and that vascular endothelial growth factor (VEGF) has a neuroprotective function in ALS mouse models. We evaluated how adenosine (A1R and A2AR) and VEGF (VEGFA, VEGFB, VEGFR-1 and VEGFR-2) system markers ar...
Endogenous VIP VPAC1 receptor activation modulates hippocampal theta burst indu...
Caulino-Rocha, Ana; Rodrigues, Nádia Carolina; Ribeiro, Joaquim A.; Cunha-Reis, DianaVasoactive intestinal peptide (VIP), acting on both VPAC1 and VPAC2 receptors, is a key modulator of hippocampal synaptic transmission, pyramidal cell excitability and long-term depression (LTD), exerting its effects partly through modulation GABAergic disinhibitory circuits. Yet, the role of endogenous VIP and its receptors in modulation of hippocampal LTP and the involvement of disinhibition in this modulatio...
Of adenosine and the blues: the adenosinergic system in the pathophysiology and...
Gomes, Joana I.; Farinha Ferreira, Jorge Miguel; Rei, Nádia; Gonçalves-Ribeiro, Joana; Ribeiro, Joaquim A.; Sebastião, Ana M; Vaz, Sandra H.Major depressive disorder (MDD) is the foremost cause of global disability, being responsible for enormous personal, societal, and economical costs. Importantly, existing pharmacological treatments for MDD are partially or totally ineffective in a large segment of patients. As such, the search for novel antidepressant drug targets, anchored on a clear understanding of the etiological and pathophysiological mech...
Caffeine has a dual influence on NMDA receptor-mediated glutamatergic transmiss...
Silva Martins, Robertta; D.M., Rombo; Ribeiro, Joana; Meneses, Carlos; Peralva Borges Martins, Vladimir Pedro; Ribeiro, Joaquim A.; Vaz, Sandra H.Caffeine, a stimulant largely consumed around the world, is a non-selective adenosine receptor antagonist, and therefore caffeine actions at synapses usually, but not always, mirror those of adenosine. Importantly, different adenosine receptors with opposing regulatory actions co-exist at synapses. Through both inhibitory and excitatory high-affinity receptors (A(1)R and A(2)R, respectively), adenosine affects ...
Caffeine has a dual influence on NMDA receptor–mediated glutamatergic transmiss...
Silva Martins, Robertta; Rombo, Diogo M.; Gonçalves-Ribeiro, Joana; Meneses, Carlos; Borges-Martins, Vladimir P. P.; Ribeiro, Joaquim A.; Vaz, Sandra H.Caffeine, a stimulant largely consumed around the world, is a non-selective adenosine receptor antagonist, and therefore caffeine actions at synapses usually, but not always, mirror those of adenosine. Importantly, different adenosine receptors with opposing regulatory actions co-exist at synapses. Through both inhibitory and excitatory high-affinity receptors (A1R and A2R, respectively), adenosine affects NMDA...
Adenosine A2A receptors facilitate synaptic NMDA currents in CA1 pyramidal neurons
Mouro, Francisco; Rombo, Diogo M.; Dias, Raquel Baptista; Ribeiro, Joaquim A.; Sebastião, Ana MBackground and purpose: NMDA receptors play a key role in both synaptic plasticity and neurodegeneration. Adenosine is an endogenous neuromodulator and through membrane receptors of the A2A subtype can influence both synaptic plasticity and neuronal death. The present work was designed to evaluate the influence of adenosine A2A receptors upon NMDA receptor activity in CA1 hippocampal neurons. We discriminated b...
Chronic, intermittent treatment with a cannabinoid receptor agonist impairs rec...
Mouro, Francisco; Ribeiro, Joaquim A.; Sebastião, Ana M; Dawson, NeilElucidating how cannabinoids affect brain function is instrumental for the development of therapeutic tools aiming to mitigate 'on target' side effects of cannabinoid-based therapies. A single treatment with the cannabinoid receptor agonist, WIN 55,212-2, disrupts recognition memory in mice. Here, we evaluate how prolonged, intermittent (30 days) exposure to WIN 55,212-2 (1 mg/kg) alters recognition memory and ...
Amyotrophic Lateral Sclerosis ALS and adenosine receptors
Sebastião, Ana M; Rei, Nádia; Ribeiro, Joaquim A.In the present review we discuss the potential involvement of adenosinergic signaling, in particular the role of adenosine receptors, in amyotrophic lateral sclerosis (ALS). Though the literature on this topic is not abundant, the information so far available on adenosine receptors in animal models of ALS highlights the interest to continue to explore the role of these receptors in this neurodegenerative diseas...