11 documents found, page 1 of 2
Evidence of fluconazole-resistant Candida species in tortoises and sea turtles
Brilhante, Raimunda Sâmia Nogueira; Rodrigues, Pedro Henrique de Aragão; Alencar, Lucas Pereira de; Riello, Giovanna Barbosa; Ribeiro, Joyce FontelesThe aim of this study was to evaluate the antifungal susceptibility of Candida spp. recovered from tortoises ( Chelonoidis spp.) and sea turtles ( Chelonia mydas , Caretta caretta , Lepidochelys oli- vacea , Eretmochelys imbricata ). For this purpose, material from the oral cavity and cloaca of 77 animals (60 tortoises and 17 sea turtles) was collected. The collected specimens were seeded on 2 % Sabouraud dextr...
Farnesol against Coccidioides posadasii : its effect on growth, ergosterol
Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves de; Caetano, Erica Pacheco; Leite, João Jaime GiffoniCoccidioidomycosis is a systemic mycosis caused by the dimorphic fungi Coccidioides spp. The treatment for chronic and/or disseminated coccidioidomycosis can be prolonged and complicated. Therefore, the search for new drugs is necessary. Farnesol is a precursor in the sterol biosynthesis pathway that has been shown to present antifungal activity. Thus, the objective of this study was to evaluate the in vitro an...
Histoplasma capsulatum var. capsulatum : taxa de conversão in vitro, detecção d...
Ribeiro, Joyce FontelesHistoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, is the most prevalent systemic mycosis in the Americas and it is frequently observed in AIDS patients. Since the beginning of the HIV epidemic, there has been a significant increase in the number of histoplasmosis cases in the Ceará state, Northeast Brazil. The lack of epidemiological data of the genotypes circulating in the Northeast region...
Effect of farnesol on growth, ergosterol biosynthesis, and cell permeability in...
Caetano, Erica Pacheco; Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves de; Leite, João Jaime GiffoniCoccidioidomycosis is a systemic mycosis caused by the dimorphic fungi Coccidioides spp. The treatment for chronic and/or disseminated coccidioidomycosis can be prolonged and complicated. Therefore, the search for new drugs is necessary. Farnesol is a precursor in the sterol biosynthesis pathway that has been shown to present antifungal activity. Thus, the objective of this study was to evaluate the in vitro an...
Synergistic Effect of Antituberculosis Histoplasma capsulatum var. capsulatum D...
Caetano, Érica Pacheco; Cordeiro, Rossana de Aguiar; Marques, Francisca Jakelyne de Farias; Brilhante, Raimunda Sâmia NogueiraThis study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plu...
Farnesol inhibits in vitro growth of the Cryptococcus neoformans species comple...
Cordeiro, Rossana de Aguiar; Nogueira, George Cândido; Brilhante, Raimunda Sâmia Nogueira; Teixeira, Carlos Eduardo Cordeiro; Mourão, Charles IelpoFarnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans. In recent years, several studies have shown that this molecule presents inhibitory effects against non-albicans Candida species, Paracoccidioides brasiliensis and bacteria. The present study aimed at determining the effect of farnesol on the growth of strains of the Cryptococcus neoformans species complex, through...
Feline histoplasmosis in Brazil : clinical and laboratory aspects and a compara...
Brilhante, Raimunda Sâmia Nogueira; Coelho, Camila Gomes Virginio; Sidrim, José Júlio Costa; Lima, Rita Amanda Chaves de; Ribeiro, Joyce FontelesThe present study described clinical and epidemiological aspects of three cases of feline histoplasmosis and compared them to previously described cases. A detailed mycological identification and antifungal susceptibility profile of each isolate are presented. Secondarily, a serological survey for anti- Histoplasma antibodies was performed with domestic and wild cats. Diseased animals presented nodular to ulcer...
Sesquiterpene farnesol contributes to Increased susceptibility to beta-Lactams ...
Brilhante, Raimunda Sâmia Nogueira; Valente, L. G. A.; Rocha, Marcos Fábio Gadelha; Bandeira, Tereza de Jesus Pinheiro GomesThis study aimed to evaluate the in vitro combination of farnesol and -lactams against Burkholderia pseudomallei . A total of 12 -lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 M. The combination of this compound with -lactams resulted in statistically significant -lactam MIC reduc- tion ( P < 0.05). This study provide...
PCR-REA as an important tool for the identification of Cryptococcus neoformans ...
Cordeiro, Rossana Aguiar; Costa, Ana Karoline Freire; Brilhante, Raimunda Sâmia Nogueira; Lima, Rita Amanda Chaves deThe extraordinary ability of Cryptococcus species to cause disease has focused the attention of scientists on finding ways to improve their identification methods. In this study, PCR- REA, manual methods (morphological and biochemical characteristics), API 20C and VITEK 2 were used to test identify a total of 30 Cryptococcus spp. from human and veterinary sources. PCR-REA was performed using the capsular region...
In vitro effect of Sulfamethoxazole-Trimethoprim against Histoplasma capsulatum...
Brilhante, Raimunda Sâmia Nogueira; Fechine, Maria Auxiliadora Bezerra; Cordeiro, Rossana de Aguiar; Rocha, Marcos Fa ́bio GadelhaThis study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for myce...