2 documents found, page 1 of 1
Working Group on Balancing Economic, Social and Ecological Objectives in Integr...
De Clercq, Adelbert; Goldsborough, David; Ramírez-Monsalve, Paulina; Ballesteros, Marta; Belgrano, Andrea; Delpeuch, Claire; DePiper, Geret; Fraga, AnaWorking Group on Balancing Economic, Social and Ecological Objectives in Integrated Assessments (WGBESEO) has two main objectives: (1) identifying objectives from legal and policy documents, and (2) understanding the implications derived from trade-offs among Economic, Social, Ecological and Institutional (ESEI) objectives. WGBESEO members are multidisciplinary professionals, including lawyers, political scient...
Unraveling fiscalin derivatives' interactions with P-glycoprotein: a computatio...
Veiga-Matos, Jéssica; dos Santos, Daniel J. V. A.; Sousa, Emília; Morales, Ana; Prieto, Marta; Remião, Fernando; Silva, RenataBackground: P-glycoprotein (P-gp), a crucial efflux transporter located on the apical membrane of vital barrier tissues, plays a critical role in the detoxification of several endobiotics and xenobiotics [1,2]. Notably, fiscalin derivatives exhibit diverse interactions with P-gp, demonstrating inhibitory or activating effects. This interaction leads to a reduction or increase in the transported substrate levels...