2 documents found, page 1 of 1
Omega 3-DHA and delta-tocotrienol modulate lipid droplet biogenesis and lipopha...
Pizato, Nathalia Marcolini Pelucio; Kiffer, Larissa Fernanda Melo Vasconcelos; Luzete, Beatriz Christina; Assumpção, José Antonio FagundesOmega 3-docosahexaenoic acid (DHA) and vitamin E Delta-tocotrienol (Delta-T3) are extensively studied as protective nutrients against cancer development. Little is known about the biological mechanisms targeted by these bioactive molecules on lipid droplet (LD) biogenesis, an important breast cancer aggressiveness marker, and the occurrence of lipophagy in breast cancer cells. The aim of this study was to inves...
Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative b...
Pizato, Nathalia Marcolini Pelucio; Luzete, Beatriz Christina; Kiffer, Larissa Fernanda Melo Vasconcelos; Corrêa, Luís HenriqueThe implication of inflammation in pathophysiology of several type of cancers has been under intense investigation. Omega-3 fatty acids can modulate inflammation and present anticancer effects, promoting cancer cell death. Pyroptosis is an inflammation related cell death and so far, the function of docosahexaenoic acid (DHA) in pyroptosis cell death has not been described. This study investigated the role of DH...