18 documents found, page 1 of 2
Xanthan Gum–Konjac Glucomannan Blend Hydrogel for Wound Healing
Alves, Andreia; Miguel, Sónia P.; Araujo, Andre RTS; Jesús Valle, María José de; Sánchez Navarro, Amparo; Correia, I.J.; Ribeiro, MP.; Coutinho, PaulaHydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application...
Recent advances on antimicrobial wound dressing: A review
Simões, Déborah; Miguel, Sónia P.; Ribeiro, MP.; Coutinho, Paula Isabel Teixeira Gonçalves; Mendonça, António; Correia, Ilídio Joaquim SobreiraSkin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrob...
Electrospun polymeric nanofibres as wound dressings: A review
Miguel, Sónia P.; Figueira, Daniela Sofia Rodrigues; Simões, Déborah; Ribeiro, MP.; Coutinho, Paula; Ferreira, Paula; Correia, Ilídio Joaquim SobreiraSkin wounds have significant morbidity and mortality rates associated. This is explained by the limited effectiveness of the currently available treatments, which in some cases do not allow the reestablishment of the structure and functions of the damaged skin, leading to wound infection and dehydration. These drawbacks may have an impact on the healing process and ultimately prompt patients’ death. For this re...
Engineering star-shaped lactic acid oligomers to develop novel functional adhes...
Santos, João; Travassos, Diana Rita Sousa; Ferreira, Paula; Marques, Dina; Gil, Maria; Miguel, Sónia; Ribeiro, MP.; Correia, Ilídio Joaquim SobreiraDirect polycondensation of L-lactic acid with a comonomer allows tailoring the properties of the product from the very first step. The viscous L-lactic acid co-oligomers with star-shaped architectures obtained were modified with three different acrylate monomers. Regardless the functionalization agent, UV curing was fast and all materials were cell compatible and promoted cell adhesion. The physical properties ...
Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membrane...
Miguel, Sónia; Ribeiro, MP.; Coutinho, Paula Isabel Teixeira Gonçalves; Correia, Ilídio Joaquim SobreiraToday, none of the wound dressings available on the market is fully capable of reproducing all the features of native skin. Herein, an asymmetric electrospun membrane was produced to mimic both layers of skin. It comprises a top dense layer (manufactured with polycaprolactone) that was designed to provide mechanical support to the wound and a bottom porous layer (composed of chitosan and Aloe Vera) aimed to imp...
Synthesis and characterization of a photocrosslinkable chitosan–gelatin hydroge...
Saraiva, Sofia Mendes; Miguel, Sónia P.; Ribeiro, MP.; Coutinho, Paula Isabel Teixeira Gonçalves; Correia, Ilídio Joaquim SobreiraIn the area of tissue engineering different approaches have been studied, so far, for promoting regeneration or replacement of damaged tissues. Among the different materials developed, hydrogels, due to their biocompatibility and similarities with the native extracellular matrix, have emerged as suitable candidates for being used for different therapeutic purposes. Herein, photocrosslinkable hydrogels, composed...
Development of a novel hydrogel for skin regeneration
Miguel, Sónia P.; Ribeiro, MP.; Correia, Ilídio Joaquim SobreiraSkin lesions are traumatic events that lead to increased fluid loss, infections, scars formation and the appearance of immunocompromised regions. The loss of skin integrity can result in significant physiological imbalances and disability or even death. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitos...
Thermoresponsive chitosan–agarose hydrogel for skin regeneration
Miguel, Sónia P.; Ribeiro, MP.; Brancal, Hugo Gonçalo Monteiro Silva Aguiar; Coutinho, Paula Isabel Teixeira Gonçalves; Correia, Ilídio Joaquim SobreiraHealing enhancement and pain control are critical issues on wound management. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan (deacetylation degree 95%) and agarose. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS...
New drug-eluting lenses to be applied as bandages after keratoprosthesis implan...
Carreira, Ana; Ferreira, Paula; Ribeiro, MP.; Correia, Tiago R.; Coutinho, Paula Isabel Teixeira Gonçalves; Correia, Ilídio Joaquim Sobreira; Gil, MariaCorneal tissue is the most commonly transplanted tissue worldwide. This work aimed to develop a new drug-eluting contact lens that may be used as a bandage after keratoprosthesis. During this work, films were produced using poly(vinyl alcohol) (PVA) and chitosan (CS) crosslinked with glyoxal (GL). Vancomycin chlorhydrate (VA) was impregnated in these systems by soaking. Attenuated total reflectance – Fourier tr...
Poly(vinyl alcohol)/chitosan asymmetrical membranes: Highly controlled morpholo...
Morgado, Patrícia I.; Lisboa, Pedro; Ribeiro, MP.; Miguel, Sónia P.; Simões, Pedro; Correia, Ilídio Joaquim Sobreira; Ricardo, Ana AguiarAsymmetrical membranes have been reported as ideal wound dressings for skin regeneration. The usual methods (dry/wet-phase inversion) to produce those specific membranes are time consuming, and in majority of the cases demand the use of harmful organic solvents. In this study, supercritical carbon dioxide (scCO2)-assisted phase inversion method was applied to prepare poly(vinyl alcohol)/chitosan (PVA/CS) asymme...