2 documents found, page 1 of 1
PNI versus SCI: the acute neuronal-specific transcriptional responses after lesion
Correia, Patrícia D.; Estrada, Veronica; Reis, Andreia; Ramos, Sara; Moura, Gabriela; Müller, Hans Werner; Bosse, Frank; Vieira, SandraSpinal cord injury (SCI) has devastating functional consequences to patients, but lacks effective treatment. Peripheral nerve injury (PNI) is a widely used model to discover new regeneration associated genes (RAGs). Various transcriptomic studies have profiled injured spinal cord or sciatic nerve tissues aiming to discover new RAGs. However, it is difficult to depict neuronal-specific responses from whole-tissu...
KIF4A: unravelling a potential spinal cord repair gene using regenerative perip...
Sousa, Bárbara M. de; Correia, Patrícia D.; Chato-Astraín, Jesús; Silva, Raquel; Müller, Hans Werner; Carriel, Víctor; Bosse, Frank; Vieira, Sandra I.Spinal cord injury (SCI) seriously impairs functions below injury level and has no effective treatment yet. Central neurons may be stimulated to regenerate in more permissive environments. Our mining for transcriptomic data from manipulated rodent SCI models presenting improved motor functions, retrieved sets of common differentially expressed genes (DEGs) involved in recovery. Amongst the up-regulated DEGs was...