22 documents found, page 1 of 3
Oromucosal Alginate Films with Zein Nanoparticles as a Novel Delivery System fo...
Rodrigues, Daniela A; Miguel, Sónia P; Loureiro, Jorge; Ribeiro, Maximiano; Roque, Fátima; Coutinho, PaulaDigoxin is a hydrophobic drug used for the treatment of heart failure that possesses a narrow therapeutic index, which raises safety concerns for toxicity. This is of utmost relevance in specific populations, such as the elderly. This study aimed to demonstrate the potential of the sodium alginate films as buccal drug delivery system containing zein nanoparticles incorporated with digoxin to reduce the number o...
Silk sericin: a promising sustainable biomaterial for biomedical and pharmaceut...
Silva, Andreia; Costa, Elisabete C.; Reis, Sara Filipa Gomes; Spencer, Carina; Calhelha, Ricardo C.; Miguel, Sónia P.; Ribeiro, MaximianoSilk is a natural composite fiber composed mainly of hydrophobic fibroin and hydrophilic sericin, produced by the silkworm Bombyx mori. In the textile industry, the cocoons of B. mori are processed into silk fabric, where the sericin is substantially removed and usually discarded in wastewater. This wastewater pollutes the environment and water sources. However, sericin has been recognized as a potential biomat...
Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membrane...
Borges, Paula Isabel; Miguel, Sónia; Ribeiro, Maximiano; Correia, IlídioToday, none of the wound dressings available on the market is fully capable of reproducing all the features of native skin. Herein, an asymmetric electrospun membrane was produced to mimic both layers of skin. It comprises a top dense layer (manufactured with polycaprolactone) that was designed to provide mechanical support to the wound and a bottom porous layer (composed of chitosan and Aloe Vera) aimed to imp...
Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membrane...
Miguel, Sónia; Ribeiro, Maximiano; Coutinho, Paula; Correia, IlídioToday, none of the wound dressings available on the market is fully capable of reproducing all the features of native skin. Herein, an asymmetric electrospun membrane was produced to mimic both layers of skin. It comprises a top dense layer (manufactured with polycaprolactone) that was designed to provide mechanical support to the wound and a bottom porous layer (composed of chitosan and Aloe Vera) aimed to imp...
Recent advances on antimicrobial wound dressing: A review
Simões, Déborah; Miguel, Sónia; Ribeiro, Maximiano; Coutinho, Paula; Mendonça, António; Correia, IlídioSkin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrob...
Recent advances on antimicrobial wound dressing: A review
Simões, Déborah; Miguel, Sónia; Ribeiro, Maximiano; Coutinho, Paula; Mendonça, António; Correia, IlídioSkin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrob...
In Vivo High-Content Evaluation of Three-Dimensional Scaffolds Biocompatibility
Oliveira, Mariana B.; Ribeiro, Maximiano; Miguel, Sónia; Neto, Ana; Coutinho, Paula; Correia, Ílidio; Mano, JoãoWhile developing tissue engineering strategies, inflammatory response caused by biomaterials is an unavoidable aspect to be taken into consideration, as it may be an early limiting step of tissue regeneration approaches. We demonstrate the application of flat and flexible films exhibiting patterned high-contrast wettability regions as implantable platforms for the high-content in vivo study of inflammatory resp...
Behaviors of outdoor workers concerning sun exposure
Fonseca, Luís; Lima, Ana; Lopes, Cátia; Gonçalves, Cristina; Ribeiro, Maximiano; Coutinho, Paula; Roque, FátimaExposure to solar ultraviolet radiations is well known as an important factor on skin cancer development. In Portugal, outdoor workers are too long exposed to the sun, and consequently to the ultraviolet radiation effects. Sun protection behaviors are important to the prevention of skin cancer.
Generic drugs and brand name products: An approach about excipients
Nogueira, Andreia; Carvalho, Leticia; Tavares, Raquel; Ribeiro, Maximiano; Coutinho, Paula; Roque, FátimaIn general excipients are considered to be “inert”, however in certain patients under certain circumstances some of them have demonstrated some activity, with increasing reports of adverse reactions. Generic drugs are required to have the same active substances, strength, dosage form and rout of administration as the brand name product, but excipients could be different. The excipients that have recognized acti...
Dextran-based hydrogel containing chitosan microparticles loaded with growth fa...
Ribeiro, Maximiano; Morgado, PI; Miguel, SP; Coutinho, Paula; Correia, IJSkin injuries are traumatic events, which are seldom accompanied by complete structural and functional restoration of the original tissue. Different strategies have been developed in order to make the wound healing process faster and less painful. In the present study in vitro and in vivo assays were carried out to evaluate the applicability of a dextran hydrogel loaded with chitosan microparticles containing e...