9 documents found, page 1 of 1
Development and Characterization of Thermal Water Gel Comprising Helichrysum it...
Saraiva, Sofia; Crespo, Ana; Vaz, Filipa; Filipe, Melanie; Santos, Daniela; Jacinto, Telma; Paiva-Santos, Ana Cláudia; Rodrigues, MárcioHelichrysum italicum essential oil (H. italicum EO) is recognized for its anti-inflammatory, antimicrobial and wound-healing properties. The main goal of the present work was the development and characterization of a gel formulation comprising H. italicum EO loaded in chitosan nanoparticles (NPs) for dermatological applications. H. italicum EO-loaded chitosan NPs presented hydrodynamic diameter and PdI of about...
Interaction of Near-Infrared (NIR)-Light Responsive Probes with Lipid Membranes...
Filipe, Hugo A. L.; Moreira, André F.; Miguel, Sónia P.; Ribeiro, Maximiano P.; Coutinho, PaulaCancer is considered a major societal challenge for the next decade worldwide. Developing strategies for simultaneous diagnosis and treatment has been considered a promising tool for fighting cancer. For this, the development of nanomaterials incorporating prototypic near-infrared (NIR)-light responsive probes, such as heptamethine cyanines, has been showing very promising results. The heptamethine cyanine-inco...
Solvent-Free Microwave Extraction of Thymus mastichina Essential Oil: Influence...
Araujo, André R.T.S.; Périno, Sandrine; Fernandez, Xavier; Cunha, Cassandra; Rodrigues, Márcio; Ribeiro, Maximiano P.; Jordao, Luisa; Silva, Lúcia A.Solvent-free microwave extraction (SFME) is a combination of microwave heating and dry distillation performed at atmospheric pressure without the addition of water or organic solvents that has been proposed as a green method for the extraction of essential oils from aromatic and medicinal herbs. In this work, SFME and the conventional techniques of steam distillation (SD) and hydrodistillation (HD) were compare...
Xanthan Gum-Konjac Glucomannan Blend Hydrogel for Wound Healing
Alves, Andreia; Miguel, Sónia P.; Araujo, André R. T. S.; de Jesús Valle, María José; Sánchez Navarro, Amparo; Correia, Ilídio J.; Ribeiro, Maximiano P.Hydrogels are considered to be the most ideal materials for the production of wound dressings since they display a three-dimensional structure that mimics the native extracellular matrix of skin as well as a high-water content, which confers a moist environment at the wound site. Until now, different polymers have been used, alone or blended, for the production of hydrogels aimed for this biomedical application...
Recent advances on antimicrobial wound dressing: A review
Simões, Déborah; Miguel, Sónia P.; Ribeiro, Maximiano P.; Coutinho, Paula; Mendonça, António G.; Correia, Ilídio J.Skin and soft tissue infections (SSTIs) have high rates of morbidity and mortality associated. Despite the successful treatment of some SSTIs, those affecting the subcutaneous tissue, fascia, or muscle delay the healing process and can lead to life-threatening conditions. Therefore, more effective treatments are required to deal with such pathological situations. Recently, wound dressings loaded with antimicrob...
Electrospun polymeric nanofibres as wound dressings: A review
Miguel, Sónia P.; Figueira, Daniela R.; Simões, Déborah; Ribeiro, Maximiano P.; Coutinho, Paula; Ferreira, Paula; Correia, Ilídio J.Skin wounds have significant morbidity and mortality rates associated. This is explained by the limited effectiveness of the currently available treatments, which in some cases do not allow the reestablishment of the structure and functions of the damaged skin, leading to wound infection and dehydration. These drawbacks may have an impact on the healing process and ultimately prompt patients’ death. For this re...
Biomimetic superhydrophobic surfaces patterned with wettable spots as implantab...
Oliveira, Mariana Braga; Ribeiro, Maximiano P.; Miguel, Sónia P.; Neto, Ana I.; Coutinho, Paula; Correia, Ilídio J.; Mano, J. F.Flat patterned superhydrophobic films are herein reported as implantable platforms containing arrays of miniaturized porous scaffolds for the high-throughput in vivo study of biomaterials. Highthroughput platforms are powerful platforms to detect hit conditions showing promising properties. However, high-content analysis of biomaterials has been mostly limited to in vitro testing where crucial information is lo...
In vivo high-content evaluation of three-dimensional scaffolds biocompatibility
Oliveira, Mariana B.; Ribeiro, Maximiano P.; Miguel, Sónia P.; Neto, Ana I.; Coutinho, Paula; Correia, Ilídio J.; Mano, J. F.While developing tissue engineering strategies, inflammatory response caused by biomaterials is an unavoidable aspect to be taken into consideration, as it may be an early limiting step of tissue regeneration approaches. We demonstrate the application of flat and flexible films exhibiting patterned high-contrast wettability regions as implantable platforms for the high-contentin vivostudy of inflammatory respon...
Ocular injectable formulation assessment for oxidized dextran-based hydrogels
Maia, João; Ribeiro, Maximiano P.; Ventura, Carla; Carvalho, Rui A.; Correia, Ilídio J.; Gil, Maria H.Initiator-free injectable hydrogels are very interesting for drug and/or cell delivery applications, since they can be administered in a minimally invasive way, and avoid the use of potentially harmful chemical initiators. In the current work, oxidized dextran crosslinked with adipic acid dihydrazide hydrogels were further characterized and tuned to produce formulations, with the aim of producing an injectable ...