38 documents found, page 1 of 4
Exploring Innovations and Key Insights in Healthcare
Cortes, Arthur R. G.; Henriques, Bruno; Sarmento, Bruno; Rodrigues, Célia Fortuna; Souza, Júlio C. M.; Tiritan, Maria Elizabeth; Brito, Nuno VieiraOn behalf of the Editorial Team of Scientific Letters, we are pleased to announce the publication of the third issue. The 2024 edition of Scientific Letters presents a diverse array of research that highlights significant advancements in health, dentistry, and clinical treatments.
The Brightness of Multidisciplinary Approaches in Health Sciences Research
Cortes, Arthur R. G.; Henriques, Bruno; Sarmento, Bruno; Rodrigues, Célia Fortuna; Souza, Júlio C. M.; Tiritan, Maria Elizabeth; Brito, Nuno VieiraOn behalf of the Editorial Team of Scientific Letters journal, we are pleased to announce the publication of the second issue. The second issue comprises four scientific papers, encompassing two reviews and two research articles. In 2023, Scientific Letters also published two special issues in the form of Books of Abstracts. These publications compile all abstracts that were accepted for presentation at the II ...
Tailoring the immobilization and release of chlorhexidine using dopamine chemis...
Alves, Diana Filipa Barros; Borges, P.; Graínha, Tânia Raquel Rodrigues; Rodrigues, Célia Fortuna; Pereira, Maria OlíviaA crucial factor in the pathogenesis of orthopedics associated infections is that bacteria do not only colonize the implant surface but also the surrounding tissues. This study aimed to engineer an antimicrobial release coating for stainless steel (SS) surfaces, to impart them with the ability to prevent Staphylococci colonization. Chlorhexidine (CHX) was immobilized using two polydopamine (pDA)-based approache...
Candida spp./Bacteria Mixed Biofilms
Rodrigues, M. Elisa; Gomes, Fernanda Isabel; Rodrigues, Célia FortunaThe ability to form biofilms is a common feature of microorganisms, such as bacteria or fungi. These consortiums can colonize a variety of surfaces, such as host tissues, dentures, and catheters, resulting in infections highly resistant to drugs, when compared with their planktonic counterparts. This refractory effect is particularly critical in polymicrobial biofilms involving both fungi and bacteria. This rev...
Advances in Candida sp. Biofilm Mannans
Romo, Jesus A.; Rodrigues, Maria Elisa Costa; Fernandes, Liliana Sousa; Papp, Csaba; Gácser, Attila; Rodrigues, Célia FortunaCandida species belong to the normal human microbiota and are commonly responsible for several clinical manifestations from mucocutaneous overgrowth to severe bloodstream infections. Candida albicans is the predominant species involved in disease conditions. Nevertheless, in the last decade, the number of infections due to non-albicans Candida (NAC) species has significantly increased. Candida species have seve...
Mice infection with Candida glabrata biofilm cells: inflammatory cell recruitme...
Rodrigues, Célia Fortuna; Correia, Alexandra; Henriques, Mariana; Vilanova, ManuelBackground: Candida glabrata is one of the most widespread Candida spp. associated to systemic candidiasis. This species is particularly critical in hospitalized, catheterized and immunosuppressed patients, due to a high drug resistance, specially to the azoles, but also to the ability to rapidly develop echinocandin resistance. Objectives: The goal of this work was to simulate a systemic infection exclusively ...
Co-immobilization of Liposomal amphotericin B and antimicrobial peptides to pre...
Alves, Diana Filipa Barros; Vaz, A.; Rodrigues, Tânia; Rodrigues, Célia Fortuna; Pereira, Maria OlíviaThe drawbacks arising from microbial colonisation of indwelling devices have been well established, as evidenced by a massive body research on antimicrobial coating strategies. Most of these strategies, however, are designed to target bacterial biofilms, being fungal biofilms or mixed biofilms much less taken into account. In real-life settings, fungi will be inevitably found in consortium with bacteria, so the...
Exploring polydopamine-based coating strategies to boost chlorohexidine immobil...
Alves, Diana Filipa Barros; Borges, Patrick; Rodrigues, Célia Fortuna; Rodrigues, Tânia; Pereira, Maria Olívia[Excerpt] Introduction Orthopedic implants have been widely used to restore the function of load-bearing joints, reducing pain and improving the life quality of millions of people every year. These devices are, however, prone to microbial infection, which remains a major cause of morbidity and mortality in modern Healthcare. The development of novel approaches to confer the surfaces of orthopedic implants with ...
Combination of Posaconazole and Amphotericin B in the treatment of Candida glab...
Rodrigues, Célia Fortuna; Alves, Diana Filipa Barros; Henriques, MarianaCandidemia cases have been increasing, especially among immunosuppressed patients. Candida glabrata is one of the most resistant Candida species, especially to the azole drugs, resulting in a high demand for therapeutic alternatives. The minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), and minimum biofilm eradication concentration (MBEC) were determined for posaconazole (Pcz) and ...
Candida glabrata biofilms: mechanisms of antifungal resistance and matrix role
Rodrigues, Célia FortunaCandidiasis are the most common fungal diseases, especially among immunosuppressed, hospitalized and patients with prolonged contact to medical devices. Generally, Candida albicans is the most encountered Candida spp., however, in the last decades, non-Candida albicans Candida (NCAC) spp. have been increasing their responsibility in the cases of candidiasis. In this group, one of the most important species is C...