18 documents found, page 1 of 2

Screening a Targeted Panel of Genes by Next-Generation Sequencing Improves Risk...

Although mutation profiling of defined genes is recommended for classification of acute myeloid leukemia (AML) patients, screening of targeted gene panels using next-generation sequencing (NGS) is not always routinely used as standard of care. The objective of this study was to prospectively assess whether extended molecular monitoring using NGS adds clinical value for risk assessment in real-world AML patients...

First report of human Thelazia callipaeda infection in Portugal

The zoonotic parasitic nematode Thelazia callipaeda, also known as the oriental eye worm, is endemic in several European countries, including Portugal. Infections may result in ocular disease in domestic and wild animals as well as humans, with more or less severe manifestations. We report the first human case of ocular thelaziosis by T. callipaeda in Portugal, a country where the parasite had already been foun...

A Pilot Study on the Metabolic Impact of Mediterranean Diet in Type 2 Diabetes:...

The Mediterranean diet (MD) has been recommended for type 2 diabetes (T2D) treatment. The impact of diet in shaping the gut microbiota is well known, particularly for MD. However, the link between MD and diabetes outcome improvement is not completely clear. This study aims to evaluate the role of microbiota modulation by a nonpharmacological intervention in patients with T2D. In this 12-week single-arm pilot st...

Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Sever...

The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categoriz...

Immature Personality Disorder: Contribution to the Definition of this Personality

Mesa 4 –“Armadilhas” urológicas: Casos clínicos; O “erro” em Medicina – Oportun...

New Prospects for the Management of Cardiovascular Effects of Tyrosine Kinase I...

The use of tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia has significantly altered the prognosis of this disease, enabling close to normal life expectancy. Despite their undeniable benefits, the use of TKIs is associated with an increased risk of side effects on the cardiovascular system, particularly of atherothrombotic events. It is therefore necessary to understand and preve...

A Novel BCR-ABL1 Mutation in a Patient with Philadelphia Chromosome-Positive B-...

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) represents the most common genetic subtype of adult ALL (20%-30%) and accounts for approximately 50% of all cases in the elderly. It has been considered the subgroup of ALL with the worst outcome. The introduction of tyrosine kinase inhibitors (TKIs) allows complete hematologic remission virtually in all patients, with improved disease-free...

A Double Philadelphia Chromosome-Positive Chronic Myeloid Leukemia Patient, Co-...

Fatores que influenciam a qualidade do sono na pessoa em unidade de cuidados in...

Introdução: O sono desempenha um papel fundamental na manutenção de uma boa saúde física e mental. As unidades de cuidados intensivos, devido à sua estrutura e funcionalidade, são locais propícios à alteração do padrão de sono dos pacientes aí internados, contribuindo para a sua privação. Todavia, existem factores nestas unidades que influenciam a qualidade do sono destes pacientes e que podem ser minimizados e...