6 documents found, page 1 of 1
Sex and body mass index impact on digit circumference for Leeds Dactylitis Inde...
Silvério-António, M; Rodrigues, AM; Teixeira, F; Tavares-Costa, J; Bernardo, A; Pimenta, S; Lagoas Gomes, J; Aguiar, R; Videira, T; Pinto, P; Santos, HObjectives: To estimate digit circumference and the impact of sex and body mass index (BMI) for the calculation of the Leeds Dactylitis Index (LDI) in psoriatic arthritis (PsA) patients with bilateral dactylitis. Methods: Digit circumference of the hands and the foot were measured with a dactylometer and were studied according to sex and BMI (divided in 4 weight categories) in healthy Portuguese subjects, using...
The prostate health index (PHI) density: Are there advantages over PHI or over ...
Garrido, MM; Ribeiro, RM; Pinheiro, LC; Holdenrieder, S; Guimarães, JTBackground and aims Overdiagnosis of prostate cancer (PCa) should be minimized. We wanted to evaluate the diagnostic performance of the prostate health index density (PHID) and compare it with that of the prostate health index (PHI) alone and of the prostate-specific antigen density (PSAD). Materials and methods 232 men scheduled for a prostate biopsy (prostate-specific antigen level: 2–10 µg/L), were enrolled....
Comparison of Three Assays for Total and Free PSA Using Hybritech and WHO Calib...
Garrido, MM; Marta, JC; Ribeiro, RM; Pinheiro, LC; Holdenrieder, S; Guimarães, JTBackground/Aim: Lack of interchangeability between prostate-specific antigen (PSA) assays could have a clinical impact. We compared PSA assays from different manufacturers and calibrations. Patients and Methods: A total of 233 men who underwent prostate biopsy (PSA: 2-10 ng/ml; Beckman Coulter Access® Hybritech® as reference) were enrolled. Total (tPSA) and free PSA (fPSA) were also measured using the Roche cob...
Are Proinflammatory Cytokines Relevant for the Diagnosis of Prostate Cancer?
Garrido, MM; Ribeiro, RM; Krüger, K; Pinheiro, LC; Guimarães, JT; Holdenrieder, S"Background/aim: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. Patients and methods: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regar...
Relevance of Circulating Nucleosomes, HMGB1 and sRAGE for Prostate Cancer Diagn...
Garrido, MM; Ribeiro, RM; Krüger, K; Pinheiro, LC; Guimarães, JT; Holdenrieder, SBackground/Aim: Evasion from cell death occurs in prostate cancer (PCa). We verified whether serum levels of cell death markers can have diagnostic value in PCa. Patients and Methods: A total of 233 men scheduled for prostate biopsy [prostate specific antigen (PSA) level: 2-10 ng/ml] were enrolled. Serum nucleosomes, nucleosomes containing the H3 histone (H3), high mobility group box 1 (HMGB1), and soluble rece...
The GO-DACT is an investigator-initiated, national, multicentric randomized pla...
Vieira-Sousa, E; Canhão, H; Alves, P; Rodrigues, AM; Teixeira, F; Tavares-Costa, J; Bernardo, A; Pimenta, S; Pimentel-Santos, .; Gomes, JL; Aguiar, RThe GO-DACT is an investigator-initiated, national, multicentric randomized placebo-controlled double-blinded trial, that assesses dactylitis as primary endpoint. Psoriatic arthritis patients naïve to methotrexate and biologic disease modifying anti-rheumatic drugs, with at least one active dactylitis, were assigned to golimumab in combination with methotrexate or placebo in combination with methotrexate, for 2...