Tese de mestrado, Neurociências, Faculdade de Medicina, Universidade de Lisboa, 2016; Intermediate Filaments are one of the major components of the cell cytoskeleton. They have an important role during stress and tissue damage. In the central nervous system, astrocytes are the most abundant cell type, and GFAP is the main component of astrocytic filaments. GFAP is involved in the reaction of astrocytes to CNS d...