5 documents found, page 1 of 1
Bases da resposta inflamatória do trato gastrintestinal
Ribeiro, Ronaldo de Albuquerque; Lima Júnior, Roberto César Pereira; Souza, Marcellus Henrique Loiola Ponte de; Leite, Caio Abner Vitorino GonçalvesA inflamação é uma resposta vascular, celular e humoral, responsável pelo processo de defesa dos organismos vivos ante agentes agressores. Essa resposta fisiológica é resultante da ação coordenada entre o sistema imunológico e o tecido no qual ocorreu a lesão. Por incorporar vários mecanismos biológicos, como a formação de edema, fagocitose, angiogênese, fibroplasia, liberação de mediadores químicos, além de ou...
Low-dose combination of alendronate and atorvastatin reduces ligature-induced a...
Dutra, Paula Goes Pinheiro; Melo, Iracema Matos; Silva, Luana Maria Castelo Melo; Benevides, Norma Maria Barros; Alencar, Nylane Maria Nunes deMaterial and Methods: Periodontitis was induced by ligature in 78 Wistar rats. Groups of six rats prophylactically received 0.9% saline (SAL), ALD (0.01 or 0.25 mg/kg subcutaneously) or ATV (0.3 or 27 mg/kg by gavage). Then, groups of six rats received the combination of ALD+ATV (0.25 mg/kg + 27 mg/kg, 0.01 mg/ kg + 0.3 mg/kg, 0.25 mg/kg + 0.3 mg/kg or 0.01 mg/kg + 27 mg/kg) prophylactically. An extra group of ...
Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from ...
Brito, Tarcisio Vieira de; Prudêncio, Rafael da Silva; Sales, Adriano Bezerra; Vieira Júnior, Francisco das Chagas; Candeira, Starley Jone NogueiraObjectives The aim of this study was to evaluate the anti-inflammatory effect of a sulphated polysaccharide fraction (PLS) extracted from the alga Hypnea musciformis and investigate the possible involvement of the nitric oxide (NO) pathway in this effect. Methods The anti-inflammatory activity of PLS was evaluated using inflammatory agents (carrageenan and dextran) to induce paw oedema and peritonitis in Swiss ...
The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplat...
Azevedo, Maria Isabel; Pereira, Anamaria Falcão; Nogueira, Ricardo Braz; Rolim, Flávio Esmeraldo; Brito, Gerly AC; Wong, Deysi Viviana T.Background: Oxaliplatin, the third-generation platinum compound, has evolved as one of the most important therapeutic agents in colorectal cancer chemotherapy. The main limiting factor in oxaliplatin treatment is painful neuropathy that is difficult to treat. This side effect has been studied for several years, but its full mechanism is still inconclusive, and effective treatment does not exist. Data suggest th...
Comparison of etoricoxib and indomethacin for the treatment of experimental per...
Azoubel, M.C.F.; Menezes, Adriana Magalhães Andrade; Bezerra, Daniel Pereira; Oriá, Reinaldo Barreto; Ribeiro, Ronaldo de AlbuquerqueWe investigated the effect of etoricoxib, a selective cyclooxygenase- 2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhib- itor, on experimental periodontitis, and compared their gastrointesti- nal side effects. A ligature was placed around the second upper left molars of female Wistar rats (160 to 200 g). Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/...