39 documents found, page 1 of 4

Decellularized dermal matrix-based hydrogels and their potential as immunomodul...

Decellularization is a process that aims to remove cellular and nuclear components from tissues, while preserving the bioactivity of the extracellular matrix (ECM) and minimizing the immunogenicity. Decellularized ECMs positively influence cell adhesion, proliferation, and differentiation, establishing them as promising biomaterials for tissue regeneration. Recent research has highlighted their potential immuno...

A new bioactive dermal substitute for wound healing and skin regeneration

Aim: Rabbit skin is an abundant agri-food by-product with interesting properties to be up-cycled into a xenogeneic dermal substrate for skin and regeneration. When decellularized, rabbit dermis preserves collagen–elastin components that can guide cell behavior. However, decellularization conditions can also influence the preservation of tissue architecture and may introduce immunogenic triggers such as damage-a...

Going green and mimetic: new ECM-based hydrogel for meniscus regeneration using...

Meniscal injuries and its subsequent progression to osteoarthritis represent a major clinical challenge, as current treatments often fail to achieve effective and complete functional restoration. An alternative regenerative approach is tissue engineering using decellularized extracellular matrix (dECM), which aims to restore meniscal structure and function. Porcine meniscus, an abundant byproduct of meat produc...

A novel ECM platform for skin regeneration: balancing structural integrity with...

Rabbit skin is an abundant agri-food by-product which can be up-cycled for generating xenogeneic extracellular matrix (ECM) scaffolds for skin tissue engineering, regeneration and modelling. When decellularized, rabbit dermis can preserve native collagen–elastin architecture and bioactive cues that support cell behaviour. However, decellularization parameters strongly influence ECM preservation, and trigger res...

Beyond DNA removal: assessing the immunological response to decellularized rabb...

Introduction: Decellularized matrices have attracted considerable attention in tissue engineering and regenerative medicine due to their ability to preserve the biochemical composition and microarchitecture of native tissues. Although DNA removal is commonly used as the main indicator of decellularization efficiency, other factors—such as endotoxin contamination, damage-associated molecular patterns, and residu...

Decellularized dermal matrix-based hydrogels and their potential as immunomodul...

Cutting-edge hybrid dressings: combining silk medical textiles and decellulariz...

Aim: Burns affect 11 million people globally each year, with 180,000 fatalities [1]. This study investigates a multilayer burn dressing combining silk fibroin (SF) fabric with highly- preserved decellularized porcine small intestine (dPSI) to support tissue regeneration and wound integration [2]. A silk sericin (SS) hydrogel is included as interface for structural integrity and anti-inflammatory benefits, enhan...

Development of a decellularized extracelular matrix from porcine aorta for hear...

Cardiovascular diseases are the leading cause of adult mortality worldwide, according to the WHO [1]. An important surgical approach for treating diseased aortic valves is the Ross procedure, in which the affected aortic valve is replaced with an autograft from the patient’s own pulmonary valve. The main concern about this procedure is linked to wall dilatation, which can lead to valve leakage and reoperation. ...

Supercritical CO2-assisted decellularization: advanced pancreatic tissue platfo...

Introduction: Decellularization is a procedure that aims to remove the cellular and antigenic material of a tissue while preserving its extracellular matrix (ECM) and biological properties. Decellularized ECM offers a natural microenvironment with significant potential for use in cell-based therapies and tissue regeneration [1]. Different protocols have been employed to decellularize tissues and organs. However...

Biohybrid dressings: integrating silk fibroin textiles with decellularized biol...

Burns affect 11 million people globally each year with 180,000 associated fatalities. This study proposes a multilayer hybrid dressing combining a silk fibroin (SF) textile with decellularized porcine small intestine (dPSI) capable of simultaneously provide wound protection and tissue regeneration. A silk sericin (SS) hydrogel was embedded into the decellularized tissue ensuring the integration with the textile...