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Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human B...
Barolli,João P.; Corrêa,Rodrigo S.; Miranda,Fabio S.; Ribeiro,Juliana U.; Bloch Jr.,Carlos; Ellena,Javier; Moreno,Virtudes; Cominetti,Márcia R.This paper describes a new series of four DNA-intercalating agents with promising anticancer activities, based on ruthenium(II) with the planar ligand dpqQX (dpqQX = dipyrido[3,2-a:2',3'-c]quinoxaline[2,3-b]quinoxaline). The complexes identified as trans-[RuCl2(dppb)(dpqQX)], cis-[RuCl2(dppb)(dpqQX)], ct-[RuCl(CO)(dppb)(dpqQX)]PF6 and ct-[RuCl2(PPh3)2(dpqQX)] (dppb = 1,4-bis(diphenylphosphine)butane and PPh3 = ...
Date: 2017
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Origin: Oasisbr