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β Lapachone blocks the cell cycle and induces apoptosis in canine osteosarcoma ...
Cruz,Vanessa S.; Rodrigues,Fernanda A.; Braga,Karla M.S.; Machado,Patrícia A.; Bianchi Filho,Cesario; Prado,Yandra C.L.; Araújo,Eugênio G.ABSTRACT: Osteosarcoma is a malignant tumor of primitive bone cells with a high incidence in dogs and humans. The need for more effective drugs with less adverse consequences has pushed the development of chemotherapeutic agents from plants and other natural sources. The aim of this study was to verify the cytotoxic effects of β-lapachone, a compound present in the sawdust of Tabebuia sp. (popularly known as ip...
Synthesis, Antitubercular and Leishmanicidal Evaluation of Resveratrol Analogues
Coimbra,Elaine S.; Santos,Juliana A.; Lima,Larissa L.; Machado,Patrícia A.; Campos,Débora L.; Pavan,Fernando R.; Silva,Adilson D.In this paper we continue our efforts in the search for new Schiff bases as resveratrol analogues as promising antitubercular and antileishmanial agents. Compounds were evaluated in vitro against Mycobacterium tuberculosis and Leishmania species. Compounds showed varying activity against promastigotes of all Leishmania species tested (concentration leading to reduction of 50% of parasite growth-IC50 values rang...