The application of conductive polymers in wound dressings presents great potential for accelerated wound healing since their high electrical conductivity and biocompatibility facilitate the delivery of external electrical stimuli to cells and tissues, promoting cell differentiation and proliferation. Electrospinning is a very straightforward method for the preparation of polymeric wound dressings capable of mim...
Understanding the complex mechanical behavior of osteochondral tissues in silico is essential for improving experimental models and advancing research in joint health and degeneration. This review provides a comprehensive analysis of the constitutive models currently used to represent the different layers of the osteochondral region, from articular cartilage to subchondral bone, including intermediate regions s...
The Centre for Rapid and Sustainable Product Development (CDRSP) of the Polytechnic of Leiria (IPL) is a leading research center with the mission of contributing to scientific and technological development through new products, materials and processes that are more sustainable, effective, and efficient. The CDRSP is an organic research unit of the IPL. It was founded in May 2007 to promote economic competitiven...
This study aimed to experimentally validate a computational fluid dynamics (CFD) model, using micro-particle image velocimetry (micro-PIV) measurements of the irrigation flow velocity field developed in confluent canals during irrigation with a side-vented needle. A microchip with confluent canals, manufactured in polydimethylsiloxane was used in a micro-PIV analysis of the irrigation flow using a side-vented n...
At birth, calves display an underdeveloped rumen that eventually matures into a fully functional rumen as a result of solid food intake and microbial activity. However, little is known regarding the gradual impact of pre-weaning diet on the establishment of the rumen microbiota. Here, we employed next-generation sequencing to investigate the effects of the inclusion of starter concentrate (M: milk-fed vs. MC: m...
Microbial communities play critical roles in the gastrointestinal tracts (GIT) of preruminant calves by influencing performance and health. However, little is known about the establishment of microbial communities in the calf GIT or their dynamics during development. In this study, next-generation sequencing was used to assess changes in the bacterial communities of the rumen, jejunum, cecum, and colon in 26 cr...
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ao nascimento, os bezerros exibem um trato gastrointestinal subdesenvolvido (TGI) cuja maturação é estritamente relacionada à colonização da microbiota. No entanto, pouco se sabe sobre os fatores que afetam o estabelecimento de comunidades de archaeas, bacterias e de fungos anaeróbicos no TGI dos bezerros, bem como as mudanças na estrutura e abundânci...
Ideal scaffolds for tissue engineering must mimic the complex characteristics of natural tissues and their mechanical performance. In this work, Polycaprolactone (PCL) and composite Polycaprolactone/Hydroxyapatite (PCL/HA) (75/25) scaffolds were produced by using an extrusion-based process called BioExtruder. The structures were characterized regarding the chemical, thermal, morphological and mechanical propert...