Introduction: The onset of Systemic Lupus Erythematosus (SLE), after 50 years of age, occurs in 3 to 18% of patients and is called Lupus Late or Lupus Senile (LESS). Objective: to describe the clinical case of a patient diagnosed with Senile Systemic Lupus Erythematosus who was admitted to the Doctor Waldemar de Alcântara General Hospital, in addition to conducting a literature review on the subject in order to...