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DNA repair gene expressions are related to bone marrow cellularity in myelodysp...

Ribeiro Jr., Howard L.; Maia, Allan Rodrigo S.; Oliveira, Roberta Taiane G. de; Costa, Marília Braga; Farias, Izabelle Rocha; Borges, Daniela de Paula

Objective To evaluate the expression of genes related to nuclear excision (ERCC8, XPA and XPC), homologous recombination and non-homologous end-joining (ATM, BRCA1, BRCA2 and LIG4) repair mechanisms, using quantitative PCR methodologies, and it relation with bone marrow cellularity in myelodysplastic syndrome (MDS). Methods and results A total of 51 adult de novo patients with MDS (3 refractory anaemia (RA), 11...

Date: 2017   |   Origin: Oasisbr
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