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(−)-α-Bisabolol inhibits preferentially electromechanical coupling on rat isola...
Siqueira, Rodrigo José Bezerra de; Ribeiro-Filho, Helder Veras; Freire, R. S.; Freire, W. B. S.; Vasconcelos-Silva, A. A.; Soares, M. A.; Lahlou, SaadPrevious findings enable us to hypothesize that (−)-α-bisabolol acts as inhibitor of voltage-dependent Ca2+ channels in smooth muscle. The current studywas aimed at consolidating such hypothesis through the recording of isometric tension, measurement of intracellular Ca2+ as well as discovery of channel target using in silico analysis. In rat aortic rings, (−)-α-bisabolol (1–1000 μM) relaxed KCl- and phenylephr...
Talking about bioelectrical potentials using rings of the mesenteric artery wit...
Ribeiro-Filho, Helder Veras; Brito, Teresinha Silva de; Lima, F. J. B.; Pinho, J. P. M.; Sousa, D. F.; Silva, Moisés Tolentino Bento daIn the present study, a practical activity is proposed to adopt an experimental approach to demonstrate the relationship between the equilibrium potential for K and transmembrane electrical potential without glass micropipettes. A conventional setup for recording contractile activity of isolated smooth muscle preparations was used based on the events elegantly described by Somlyo and Somlyo in the 1960s. They s...