4 documents found, page 1 of 1
Connexin43 promotes exocytosis of damaged lysosomes through actin remodelling
Domingues, Neuza S.; Catarino, Steve; Cristóvão, Beatriz; Rodrigues, Lisa; Carvalho, Filomena A; Sarmento, Maria João; Zuzarte, MónicaA robust and efficient cellular response to lysosomal membrane damage prevents leakage from the lysosome lumen into the cytoplasm. This response is understood to happen through either lysosomal membrane repair or lysophagy. Here we report exocytosis as a third response mechanism to lysosomal damage, which is further potentiated when membrane repair or lysosomal degradation mechanisms are impaired. We show that ...
Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plect...
Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Massenzio, Francesca; Spigarelli, RenatoGlioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options. Therefore, novel therapies centered around plant-derived compounds emerge as a compelling avenue to enhance patient survival and well-be...
Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading
Aires, Inês Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel Sofia Freitas; Ferreira-Rodrigues, Magda; Girão, Henrique; Ambrósio, António FranciscoMicroglial cells are the neuroimmune competent cells of the central nervous system. In the adult, microglia are responsible for screening the neuronal parenchyma searching for alterations in homeostasis. Chronic neuroinflammation plays a role in neurodegenerative disease. Indeed, microglia-mediated neuroinflammation is involved in the onset and progression of several disorders in the brain and retina. Microglia...
Exosomes and STUB1/CHIP cooperate to maintain intracellular proteostasis
Ferreira, João Vasco; Soares, Ana Rosa; Ramalho, José S.; Ribeiro-Rodrigues, Teresa; Máximo, Catarina; Zuzarte, Mónica; Girão, Henrique; Pereira, PauloDeregulation of proteostasis is a main feature of many age-related diseases, often leading to the accumulation of toxic oligomers and insoluble protein aggregates that accumulate intracellularly or in the extracellular space. To understand the mechanisms whereby toxic or otherwise unwanted proteins are secreted to the extracellular space, we inactivated the quality-control and proteostasis regulator ubiquitin l...