12 documents found, page 1 of 2
Tumor-infiltrating T cells in skin basal cell carcinomas and squamous cell carc...
Cunha, Daniela; Neves, Marco; Silva, Daniela; Silvestre, Ana Rita; Borralho, Paula; Arrobas, Fernando; Ribot, Julie; Ferreira, Fernando; Moita, Luís F.Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are high-incidence, non-melanoma skin cancers (NMSCs). The success of immune-targeted therapies in advanced NMSCs led us to anticipate that NMSCs harbored significant populations of tumor-infiltrating lymphocytes with potential anti-tumor activity. The main aim of this study was to characterize T cells infiltrating NMSCs. Flow cytometry and immuno...
New immune regulators of sciatic nerve regeneration? Lessons from the neighborhood
Bombeiro, André; Fernandes, Rodrigo G. Q.; Ribot, JulieFor decades, the immune system has been associated with host protection against infectious pathogens or tumors, while also contributing to autoimmunity. Notwithstanding, this paradigm is now changing, with recent studies highlighting novel roles for immune mediators in the maintenance of steady-state tissue homeostasis. In this perspective, we review some of the latest findings featuring immune modulators of th...
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of ...
Cristiano Brigas, Maria Helena; Ribeiro, Miguel; Coelho, Joana E; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, EmilieNeuroinflammation in patients with Alzheimer's disease (AD) and related mouse models has been recognized for decades, but the contribution of the recently described meningeal immune population to AD pathogenesis remains to be addressed. Here, using the 3xTg-AD model, we report an accumulation of interleukin-17 (IL-17)-producing cells, mostly γδ T cells, in the brain and the meninges of female, but not male, mic...
γδ T cells, Tregs and epithelial cells interact with IL-33 in the lung
Darrigues, Julie; Ribot, JulieMucosal barriers are composed of an organized network of tightly joined cells that act as a critical first line of defense against pathogens. With their tissue homing properties and ability to sense environmental signals, gamma delta (γδ) T cells play a key role in this process. In particular, they contribute to immune surveillance and protect the host against infection through the production of IL-17A. For ins...
MicroRNA‐181a restricts human γδ T cell differentiation by targeting Map3k2 and...
Gordino, Gisela; Costa Pereira, Sara; Corredeira, Patrícia; Alves, Patrícia; Costa, Luis; Gomes, Anita Q.; Silva-Santos, Bruno; Ribot, Julieγδ T cells are a conserved population of lymphocytes that contributes to anti-tumor responses through its overt type 1 inflammatory and cytotoxic properties. We have previously shown that human γδ T cells acquire this profile upon stimulation with IL-2 or IL-15, in a differentiation process dependent on MAPK/ERK signaling. Here, we identify microRNA-181a as a key modulator of human γδ T cell differentiation. We...
γδ T cells in tissue physiology and surveillance
Ribot, Julie; Lopes, Noëlla; Silva-Santos, Brunoγδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By rapidly producing large amounts of cytokines, γδ T cells make key contributions to immune responses in these tissues. In addition to their immune surveillance activities, recent reports have unravelled exciting new roles for γδ T cells in ste...
Microbiota-dependent expansion of testicular IL-17-producing Vγ6+ γδ T cells up...
Wilharm, Anneke; Cristiano Brigas, Maria Helena; Sandrock, Inga; Ribeiro, Miguel; Amado, Tiago; Reinhardt, Annika; Demera, Abdi; Hoenicke, LisaγδT cells represent the majority of lymphocytes in several mucosal tissues where they contribute to tissue homoeostasis, microbial defence and wound repair. Here we characterise a population of interleukin (IL) 17-producing γδ (γδ17) T cells that seed the testis of naive C57BL/6 mice, expand at puberty and persist throughout adulthood. We show that this population is foetal-derived and displays a T-cell recepto...
miR-181a negatively regulates human γδ T cell differentiation into anti-tumor e...
Gordino, Gisela; Pereira, Sara; Gomes, Anita Q.; silva-Santos, Bruno; Ribot, JulieCytotoxicity and IFN-γ production by human γδ T cells underlie their potent anti-tumor functions. importantly, we have previously shown that ex vivo-isolated γδ thymocytes produced negligible IFN-γ and lacked cytolytic activity against leukemia cells but could acquire those properties upon stimulation with IL-2 or IL-15. This notwithstanding, the role of post-transcriptional mechanisms mediated by miRs in the a...
γδ-T cells promote IFN-γ–dependent Plasmodium pathogenesis upon liver-stage inf...
Ribot, Julie; Neres, Rita; Zuzarte-Luis, Vanessa; Gomes, Anita Q.; Mancio-Silva, Liliana; Mensurado, Sofia; Neves, Daniel; Monteiro Dos Santos, MiguelCerebral malaria (CM) is a major cause of death due to Plasmodium infection. Both parasite and host factors contribute to the onset of CM, but the precise cellular and molecular mechanisms that contribute to its pathogenesis remain poorly characterized. Unlike conventional αβ-T cells, previous studies on murine γδ-T cells failed to identify a nonredundant role for this T cell subset in experimental cerebral mal...
IL-17+ γδ T cells as kick-starters of inflammation
Papotto, Pedro H.; Ribot, Julie; Silva-Santos, BrunoShortly after the discovery of interleukin 17 (IL-17)-producing CD4+ helper T cells (TH17 cells), it was found that γδ T cells can also secrete large amounts of this pro-inflammatory cytokine. A decade later, it is now known that IL-17+ γδ T cells (γδ17 T cells) are often the main providers of IL-17A in various models of inflammatory diseases, while they also contribute to protective immune responses to infecti...