6 documents found, page 1 of 1
InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in I...
Magalhães, AC; Ricardo, S; Moreira, AC; Nunes, M; Tavares, M; Pinto, RJ; Gomes, MS; Pereira, LThe recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the scientific community to acquire knowledge in real-time, when total lockdowns and the interruption of flights severely limited access to reagents as the global pandemic became established. This unique reality made researchers aware of the importance of designing efficient in vitro set-ups to evaluate infectious kinet...
Generation of Two Paclitaxel-Resistant High-Grade Serous Carcinoma Cell Lines W...
Nunes, M; Silva, PMA; Coelho, R; Pinto, C; Resende, A; Bousbaa, H; Almeida, GM; Ricardo, SDebulking surgery followed by chemotherapy are the standard of care for high-grade serous carcinoma. After an initial good response to treatment, the majority of patients relapse with a chemoresistant profile, leading to a poor overall survival. Chemotherapy regimens used in high-grade serous carcinomas are based in a combination of classical chemotherapeutic drugs, namely, Carboplatin and Paclitaxel. The mecha...
Recycling the purpose of old drugs to treat ovarian cancer
Nunes, M; Abreu, MH; Bartosch, C; Ricardo, SThe main challenge in ovarian cancer treatment is the management of recurrences. Facing this scenario, therapy selection is based on multiple factors to define the best treatment sequence. Target therapies, such as bevacizumab and polymerase (PARP) inhibitors, improved patient survival. However, despite their achievements, ovarian cancer survival remains poor; these therapeutic options are highly costly and can...
Regulation of invasion and peritoneal dissemination of ovarian cancer by mesoth...
Coelho, R; Ricardo, S; Amaral, AL; Huang, YL; Nunes, M; Neves, JP; Mendes, N; López, MN; Bartosch, C; Ferreira, V; Portugal, R; Lopes, JM; Almeida, RPeritoneal dissemination is a particular form of metastasis typically observed in ovarian cancer and the major cause for poor patient’s outcome. Identification of the molecular players involved in ovarian cancer dissemination can offer an approach to develop treatment strategies to improve clinical prognosis. Here, we identified mesothelin (MSLN) as a crucial protein in the multistep process of peritoneal disse...
Mucins and truncated O-glycans unveil phenotypic discrepancies between serous o...
Coelho, R; Marcos-Silva, N; Mendes, N; Pereira, D; Brito, C; Jacob, F; Steentoft, C; Mandel, U; Clausen, H; David, L; Ricardo, SOptimal research results rely on the selection of cellular models capable of recapitulating the characteristics of primary tumours from which they originate. The expression of mucins (MUC16 and MUC1) and truncated O-glycans (Tn, STn and T) represents a characteristic footprint of serous ovarian carcinomas (SOCs). Therefore, selecting ovarian cancer (OVCA) cell lines that reflect this phenotype is crucial to exp...
Reacções adversas a medicamentos como causa de internamento
Vasconcelos, P; Ricardo, S; Bragança, NIntrodução: As reacções adversas a medicamentos (RAM) são uma importante causa de admissão hospitalar, morbilidade e mortalidade. Objectivos: Analisar a importância das RAM como causa de internamento num Serviço de Medicina e caracterizar estes doentes tentando identificar factores de risco para a ocorrência destas reacções. Material e métodos: Analisámos as notas de alta dos doentes admitidos de 01/01/2010 a 3...