19 documents found, page 1 of 2
Ivermectin decreases the expression of ALDH1 in ovarian cancer cell lines in co...
Santos, Cláudia; Oliveira, Érica; Ally, Sofia; Nunes, Mariana; Resende, Albina; Ricardo, SaraBackground: Cell Microarray (CMA) technology has been established as an essential tool for advancing cancer studies, allowing for the simultaneous protein analysis of multiple samples [1]. This method facilitates the exploration of various biomarkers associated with diagnosis, prognosis, and therapeutic response, making evaluation processes more efficient and comprehensive [1]. Carboplatin and paclitaxel are co...
Lymphocyte population characterization in ovarian cancer microenvironment
Nunes, Ana Rita; Rodrigues, Tomás; Garcez, Fernanda; Ricardo, Sara; Resende, Albina Dolores; Batista-Pinto, CarlaBackground: Ovarian cancer (OC) is one of the most common gynecological cancers, with poor prognosis and high mortality [1]. A key early sign of OC is the presence of ascites [2], indicating transcoelomic metastasis and tumor spread within the peritoneal cavity [3]. The accumulation of this serous fluid facilitates migration of tumor cells, which detach from the primary tumor (PT) in multicellular aggregates, m...
Immune microenvironment of the omentum in appendicitis: a phenotypic perspectiv...
Marques, Sara; Gaspar, Márcio; Garcez, Fernanda; Batista-Pinto, Carla; Ricardo, Sara; Resende, Albina DoloresBackground: The omentum plays a crucial role in managing inflammation and combating infections, particularly in acute appendicitis [1]. This fat-rich fold of the peritoneum contains lymphoid structures known as “Milky Spots”, which house several types of phenotypically and functionally distinct immune cells, including macrophages and lymphocytes, that contribute to its protective function [1,2]. Among these, T ...
A first-in-class inhibitor of homologous recombination DNA repair counteracts t...
Calheiros, Juliana; Silva, Rita; Barbosa, Filipa; Morais, João; Moura, Sara Reis; Almeida, Sofia; Fiorini, Elena; Mulhovo, Silva; Aguiar, Tatiana QuintaBackground Pancreatic ductal adenocarcinoma (PDAC) is among the cancer types with poorest prognosis and survival rates primarily due to resistance to standard-of-care therapies, including gemcitabine (GEM) and olaparib. Particularly, wild-type (wt)BRCA tumours, the most prevalent in PDAC, are more resistant to DNA-targeting agents like olaparib, restraining their clinical application. Recently, we disclosed a m...
In Silico Identification of Six Mushroom-Derived Sterol and Triterpenoid Compou...
Fonseca, Jéssica; Shiraishi, Carlos S.H.; Abreu, Rui M.V.; Ricardo, Sara; Vaz, Josiana A.The overexpression of P-glycoprotein (P-gp) is often directly related to multidrug resistance (MDR), one of the greatest challenges in cancer treatment. This transmembrane efflux pump decreases the intracellular concentrations of chemotherapy drugs, reducing their effectiveness and resulting in treatment failure. This work used in silico methods to assess the potential of bioactive chemicals produced from mushr...
Redefining ovarian cancer treatment with a first-in-class inhibitor of homologo...
Saraiva, Lucília H.; Pardal de Matos, Ana C.; Mota, Inês; Moura, Sara; Ciucci, Alessandra; Aguiar, Tatiana Quinta; Ricardo, Sara; Almeida, Maria I.Background: High-grade serous ovarian cancer (HGSOC) is characterized by poor prognosis and low overall survival. While PARP inhibitors (PARPis) are standard maintenance therapy for BRCA-mutated HGSOC (10% of cases), acquired resis-tance develops in over 60% of patients. We identied BBIT20, a rst-in-class inhibitor of the BRCA1-BARD1 interaction that disrupts homologous recombination (HR) DNA repair. Methods: B...
The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer C...
Fonseca, Jéssica; Vaz, Josiana A.; Ricardo, SaraChemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for cancer therapies, offering a possible solution to overcome chemoresistance. This systematic review aimed to explore the role of mushroom extracts in enhancing chemotherapy and reversing chemoresistance in cancer cells. We searched the PubMed, Web of Science and...
Que outra utilidade clínica poderão ter as ascites no carcinoma do ovário?
Nunes, Mariana; Nunes, Diana; Abreu, Miguel; Bartosch, Carla; Ricardo, SaraAscites in ovarian carcinoma (OC) is one of the signs of peritoneal metastization and is often present at diagnosis in advanced stages and disease recurrence. This serous fluid can support the diagnosis and drained for symptomatic relief in advanced phases and subsequently discarded. In this context, ascitic fluid analysis is a unique opportunity to monitor the kinetics of tumor cells during disease progression...
Ivermectin: an ally to reverse P-glycoprotein-associated multidrug resistance i...
Nunes, Mariana; Ricardo, SaraBackground: The standard treatment for ovarian cancer (OC) involves carboplatin and paclitaxel, which can be followed by PARP inhibitors (PARPi) [1]; however, resistance to therapy is common. Increased drug efflux is a well-described mechanism of resistance to paclitaxel and PARPi [2]. Prior treatment with paclitaxel may increase P-gp upregulation and indirectly induce PARPi resistance [3]. Ivermectin...
Omentum picture: unraveling the enigma of the immune microenvironment in append...
Gaspar, Márcio; Rodrigues, Tomás; Nunes, Ana Rita; Garcez, Fernanda; Ricardo, Sara; Batista-Pinto, Carla; Resende, Albina DoloresBackground: Appendix obstruction triggers inflammation and exaggerated immune responses, leading the omentum, rich in Milky Spots (MS) housing immune cells, to play a vital role in peritoneal immunity. These MS collect antigens and pathogens, inducing immune responses like inflammation, immune tolerance, or fibrosis [1,2]. Their activities, including angiogenesis, stem cell differentiation, and immune resp...