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Linseed Oil Nanoemulsion with Pluronic® F127 Loaded with Betulinic Acid: Prepar...
Rebouças,Louhana M.; Sousa,Alexandre C. C.; Gramosa,Nilce V.; Araújo,Tamara G. de; Oliveira,Fátima de Cássia E. de; Pessoa,Cláudia do ÓThe main objective of this work was to develop a nanoemulsion based on linseed oil and betulinic acid, stabilized with Pluronic F127 and polyglycerol polyricinoleate, for anticancer applications. The nanoemulsions were synthesized by ultrasound and evaluated for in vitro cytotoxicity, particle size, polydispersity index, zeta potential, morphology, encapsulation efficiency, storage stability, rheology and in vi...
Spondias purpurea L. Stem Bark Extract: Antioxidant and in vitro Photoprotectiv...
Rodrigues,Francisco Alessandro M.; Giffony,Priscylla S.; Santos,Sarah B. F. dos; Guedes,Jhonyson A. C.; Ribeiro,Maria Elenir N. P.; Araújo,Tamara G. dePlant phenolic extracts are widely recognized as an important source of natural antioxidant substances and potential compounds for cosmetic formulations. This study aimed to evaluate the chemical profile, photoprotective and antioxidant activities of stem bark extract of Spondias purpurea L. (ciriguela) and its application in photoprotective formulations. Thirty phenolic constituents were annotated by ultra-per...
Chitosan and Agaricus brasiliensis Polysaccharides Films: A Preliminary Study
Gonzaga,Maria L. C.; Campelo,Matheus. S.; Saraiva,Katarina B.; Santos,Alan Q. S.; Leal,Luzia K. A. M.; Ricardo,Nágila M. P. S.; Soares,Sandra A.The known biotechnological properties of chitosan and the recent biological activities attributed to polysaccharides from Agaricus brasiliensis have been of interest to obtain films constituted by these two polymers. The glucans obtained from the mushroom inhibited about 96.5% of the ferrous ion, besides not promoting a significant increase of lactate dehydrogenase enzyme (LDH), which indicates that the polysac...
BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION
Lopes,Karen P. S.; Cavalcante,Igor M.; Silva,Raquel F. da; Brito,Débora H. A. de; Fechine,Lillian M. U. D.; Moreira,Denise R.; Vieira,Ícaro G. P.Micelles have aroused interest due to their ability to assist in the transport of poorly soluble drugs. In this study the mixture of copolymers F127/E45S8 in different proportions (F/ES 30/70, 50/50 and 70/30) was performed to improve the bioavailability of griseofulvin and quercetin. The results of cytotoxicity (MTT assay) revealed that the copolymers F127 and E45S8 had considerable biocompatibility and did no...
Adenanthera pavonina GALACTOMANNAN FOR CONTROLLED DELIVERY OF RUTIN - A PRELIMI...
Nobre,Karine A.; Soares,Carlos E. A.; Vieira,Ícaro G. P.; Almeida,Raimundo R. de; Moreira,Renato de A.; Araújo,Tamara G. de; Ribeiro,Maria E. N. P.Improving the development of modified release matrix systems strictly depends on selecting an appropriate agent capable of controlling the drug's release. In this study, Adenanthera pavonina galactomannan was investigated as a potential basis for developing a controlled release of rutin. This galactomannan was extracted, purified and characterized by GPC, NMR and FT-IR spectroscopy. The mannose/galactose ratio ...
Novos surfactantes alquil poliglicosídicos à base de amilose extraída da batata...
França,Francisco C. F. de; Moreira,Denise R.; Almeida,Raimundo R. de; Rodrigues,Francisco H. A.; Ribeiro,Maria E. N. P.; Ricardo,Nágila M. P. S.Alkyl polyglycosides (APGs) are new biodegradable surfactants, non-toxic, synthesized from abundant renewable sources, potentially more appropriate than anionic surfactants. A range of glycosides denoted APG-Cy was synthesized by the Köenig-Knorr reaction using C10, C16 and C18 alcohols and derived from the degradation of amylose from English potato. The molecular structures of the glycosides were characterized...
Binary systems of Brij® surfactants with Pluronic® F127 as griseofulvin carrier
Coelho,Ethanielda de L.; Moura,Carolina L. de; Maia,Deyse de S.; Araújo,Tamara G. de; França,Francisco C. F. de; Ricardo,Nadja M. P. S.The binary mixtures of Brij® surfactant and Pluronic® F127 were studied as carriers of griseofulvin. The F127 systems and Brij® 78 (C18H37E20), Brij® 98 (C18H35E20) and Brij® 700 (C18H37E100) were prepared in the proportions 10/90, 30/70, 50/50 and 70/30, respectively. The characterizations were carried out by tube inversion, rheology, particle size, and theoretical cmcs. The griseofulvin solubilization tests w...
MODIFICAÇÃO QUÍMICA DA PECTINA DO MELÃO CAIPIRA (Cucumis melo VAR. ACIDULUS)
Sousa,André L. N. de; Ribeiro,Ana C. B.; Santos,Denilton G.; Ricardo,Nadja M. P. S.; Ribeiro,Maria E. N. P.; Cavalcanti,Eveline S. B.; Cunha,Arcelina P.Melon is one of the most widely consumed fruits in the world. In Brazil, 60% of the production is for domestic consumption, with these fruits deemed to be of lower commercial value. For the first time, pectin has been extracted from this species of melon. So the extraction of this polysaccharide can be used as an alternative to increase the value of the fruit, improving profits in the domestic market where it c...
Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolac...
Dutra,Lillian M. U.; Cavalcante,Igor M.; Brito,Débora H. A. de; Vieira,Ícaro G. P.; Trevisan,Maria T. S.; Ribeiro,Maria E. N. P.; Yeates,Stephen G.Binary mixtures of block copolymers E114CL20 and E97P69E97 (F127(®)) were prepared in order to tailor a drug delivery system with synergistic effect, concerning dilution stability and high drug solubility. Both reduction of the critical micelle concentrations (CMC) values and enhance hydrophobic drug solubility in F127/E114CL20 mixtures (30-50 wt.%) were observed by addition of the diblock E114CL20, also reachi...
Preliminary Evaluation of Novel Triglyceride-Based Nanocomposites for Biomedica...
Almeida,Raimundo R. de; Gallo,Juan; Silva,Aiêrta C. C. da; Silva,Ana K. O. da; Pessoa,Otilia D. L.; Araújo,Tamara G.; Leal,Luzia K. A. M.This work describes the development and characterization of triglyceride-based magnetic nanocomposites for application in magnetic hyperthermia and controlled drug delivery. The magnetic solid lipid nanocomposites (MSLN) constituted by mixtures of trilaurin-tricaprylin and trilaurin-tricaprin have been successfully obtained by emulsification-solvent evaporation method. The developed MSLNs were subjected to an e...