28 documents found, page 1 of 3
Metabolomics of Methylphenidate and Ethylphenidate: Implications in Pharmacolog...
Ricardo Jorge Dinis OliveiraMethylphenidate (MPH) is primarily indicated for attention-deficit hyperactivity disorder and narcolepsy therapy. A marked individual variability in the dose-response has been observed, and therefore dosage must be titrated for optimal therapeutic effect with minimal toxicity. This variability has been claimed to be predominantly pharmacokinetic. Moreover, due to its similar pharmacodynamics to amphetamine, MPH...
Morphological transition of Helicobacter pylori adapted to water
Fernandes, RM; Silva, H; Ricardo Jorge Dinis Oliveira; Almeida, C; Azevedo, NF; Vieira, MJAim: This study aims to investigate the morphological transition of Helicobacter pylori during adaptation to water. Materials & methods: Different strains were adapted to water. Changes regarding cultivability and cellular morphology were recorded. Expression of 11 genes involved in H. pylori morphological changes was evaluated by real-time PCR. Results: H. pylori presented increased cultivability in water afte...
Data analysis of "krokodil" samples obtained by street-like synthesis
Neves, JF; Alves, EA; Jose X Soares; Sara Cravo; Silva, AMS; Netto, ADP; Felix Carvalho; Ricardo Jorge Dinis Oliveira; Carlos AfonsoThe data described in this work is related to be the subject of an article in the Forensic Science International, titled: "The harmful chemistry behind "krokodil": street-like synthesis and product analysis" (http://dx.doi.org/10.1016/j.forsciint.2015.07.042) [1]. The data presented here provides additional description of the chemical profile of "krokodil". Physicochemical and organoleptic characteristics, TLC ...
Comparative study of the neurotoxicological effects of tramadol and tapentadol ...
Faria, J; Barbosa, J; Queiros, O; Moreira, R; Felix Carvalho; Ricardo Jorge Dinis OliveiraOpioid therapy and abuse are increasing, justifying the need to study their toxicity and underlying mechanisms. Given opioid pharmacodynamics at the central nervous system, the analysis of toxic effects in neuronal models gains particular relevance. The aim of this study was to compare the toxicological effects of acute exposure to tramadol and tapentadol in the undifferentiated human SH-SY5Y neuroblastoma cell...
Comparative metabolism of tramadol and tapentadol: a toxicological perspective
Barbosa, J; Faria, J; Queiros, O; Moreira, R; Felix Carvalho; Ricardo Jorge Dinis OliveiraTramadol and tapentadol are centrally acting, synthetic opioid analgesics used in the treatment of moderate to severe pain. Main metabolic patterns for these drugs in humans are well characterized. Tramadol is mainly metabolized by cytochrome P450 CYP2D6 to O-desmethyltramadol (M1), its main active metabolite. M1 and tapentadol undergo mainly glucuronidation reactions. On the other hand, the pharmacokinetics of...
Metabolomics of methadone: clinical and forensic toxicological implications and...
Ricardo Jorge Dinis OliveiraMethadone is a full -opioid receptor agonist used in the treatment of heroin addiction. It is commercialized as a racemic mixture with considerable variability in the pharmacokinetics and pharmacodynamics between individuals that can affect dose-response and toxicological profile. This review aims to discuss metabolomics of methadone, namely by presenting all major and minor metabolites and pharmacokinetic drug...
Metabolomics of Delta(9)-tetrahydrocannabinol: implications in toxicity
Ricardo Jorge Dinis OliveiraCannabis sativa is the most commonly used recreational drug, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) being the main addictive compound. Biotransformation of cannabinoids is an important field of xenobiochemistry and toxicology and the study of the metabolism can lead to the discovery of new compounds, unknown metabolites with unique structures and new therapeutic effects. The pharmacokinetics of Delta(9)-T...
Oxidative and Non-Oxidative Metabolomics of Ethanol
Ricardo Jorge Dinis OliveiraBackground: It is well known that ethanol can cause significant morbidity and mortality, and much of the related toxic effects can be explained by its metabolic profile. Objective: This work performs a complete review of the metabolism of ethanol focusing on both major and minor metabolites. Method: An exhaustive literature search was carried out using textual and structural queries for ethanol and related know...
Human and experimental toxicology of orellanine
Ricardo Jorge Dinis Oliveira; Soares, M; Rocha Pereira, C; Felix CarvalhoOrellanine is a nephrotoxic toxin produced by some mushroom species of the Cortinarius genus, typically found in Europe and North America. The nephrotoxicity of Cortinarius orellanus is well known. and was first recognized in the I 950s when this mushroom was identified as the cause of a mass poisoning in Poland. Typically, onset of symptoms is delayed for 1-2 weeks after ingestion. Some patients suffer mild ga...
Response to the comment on "Promising blood-derived biomarkers for estimation o...
Ricardo Jorge Dinis Oliveira; Felix Carvalho; Costa, I; Silvestre, R; Teresa MagalhãesFollowing Meurs and Szykula's comment on our published article titled "Promising blood-derived biomarkers for estimation of the postmortem interval", we recognize the importance of the issues raised, but we would like to emphasize that these contain some misinterpretations and that most of the points were already discussed in depth in our manuscript particularly in the conclusion section. We also aim to highlig...