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Efeitos comportamentais da exposição na puberdade de camundongos machos e fêmea...

Joaquim, Andréia de Oliveira; Macrini, Daclé Juliane; Ricci, Esther Lopes; Rodrigues, Paula Andreotti; Spinosa, Helenice de Souza

The present study aims to investigate the effects of pre-pubertal exposure of male and female mice to a commercial formulation of glyphosate on sexual dimorphism observed in animal models of emotionality, anxiety and depression. For this, mice were exposed from 23 days of age (PND) until PND 45 to glyphosate (50 mg/kg, per os) or saline solution, and, ten days after the end of treatments, male and female mice w...

Date: 2014   |   Origin: Oasisbr


Behavioral teratogenicity induced by maternal food restriction: maternal cannib...

Ricci, Esther Lopes; Bernardi, Maria Martha; Górniak, Silvana Lima; Spinosa, Helenice Souza

http://dx.doi.org/10.5007/2175-7925.2014v27n2p185Recent studies have attributed the presence of several toxic chemicals during pregnancy to maternal malnutrition. A deficit in maternal nutritional status may be crucial for the development of teratogenicity. However, nowadays, the concept of teratogenesis is not restricted to structural abnormalities, but, also, to functional changes, such as, for instance, thos...

Date: 2014   |   Origin: Oasisbr

Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects i...

Ricci, Esther Lopes; Ferreira Jr, Vladimir; Habr, Soraya Ferreira; Macrini, Daclé Juliani; Bernardi, Maria Martha; Spinosa, Helenice de Souza

Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neur...

Date: 2013   |   Origin: Oasisbr

Efeitos comportamentais da exposição aguda ao gliposato em camundongos Balb/c m...

Joaquim, Andréia de Oliveira; Spinosa, Helenice de Souza; Macrini, Daclé Juliane; Rodrigues, Paula Andreotti; Ricci, Esther Lopes

Neste trabalho investigou-se em camundongos BALB/c, machos e fêmeas, os efeitos comportamentais da exposição aguda a uma formulação comercial do glifosato (GF) em uma dose duas vezes maior que a dose sem efeito observado(NOAEL). A neurotoxicidade aguda ao GF foi determinada por meio da análise da atividade geral, de parâmetros sensoriais, psicomotores, do sistema nervoso central e autônomo em machos e fêmeas. O...

Date: 2012   |   Origin: Oasisbr

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