3 documents found, page 1 of 1
No evidence for an mtDNA role in sperm motility: data from complete sequencing ...
Pereira, L; Gonçalves, J; Franco-Duarte, R; Silva, J; Rocha, T; Arnold, C; Richards, M; Macaulay, VThe first complete mitochondrial DNA (mtDNA) sequences (approximately 16,569 bp) in 20 patients with asthenozoospermia and a comparison with 23 new complete mtDNA sequences in teratoasthenozoospermic individuals, confirmed no sharing of specific polymorphisms or specific mitochondrial lineages between these individuals. This is strong evidence against the accepted claim of a major role played by mtDNA in male f...
Evaluating the forensic informativeness of mtDNA haplogroup H sub-typing on a E...
Pereira, L; Richards, M; Goios, A; Alonso, A; Albarrán, C; Garcia, O; Behar, DM; Gölge, M; Hatina, J; Al-Gazali, L; Bradley, DG; Macaulay, V; Amorim, AThe impact of phylogeographic information on mtDNA forensics has been limited to the quality control of published sequences and databases. In this work we use the information already available on Eurasian mtDNA phylogeography to guide the choice of coding-region SNPs for haplogroup H. This sub-typing is particularly important in forensics since, even when sequencing both HVRI and HVRII, the discriminating power...
High-resolution mtDNA evidence for the late-glacial resettlement of Europe from...
Pereira, L; Richards, M; Goios, A; Alonso, A; Albarrán, C; Garcia, O; Behar, DM; Gölge, M; Hatina, J; Al-Gazali, L; Bradley, DG; Macaulay, V; Amorim, AThe advent of complete mitochondrial DNA (mtDNA) sequence data has ushered in a new phase of human evolutionary studies. Even quite limited volumes of complete mtDNA sequence data can now be used to identify the critical polymorphisms that define sub-clades within an mtDNA haplogroup, providing a springboard for large-scale high-resolution screening of human mtDNAs. This strategy has in the past been applied to...