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Epigenetic adaptations of the masticatory mucosa to periodontal inflammation

Richter, Gesa M; Kruppa, Jochen; Keceli, H Gencay; Ataman-Duruel, Emel Tuğba; Graetz, Christian; Pischon, Nicole; Wagner, Gunar; Rendenbach, Carsten

Background: In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The ...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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