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Biodegradable PEG-dendritic block copolymers: Synthesis and biofunctionality as...
Leiro, V; Garcia, JP; Moreno, PM; Spencer, AP; Fernandez-Villamarin, M; Riguera, R; Fernandez-Megia, E; Pêgo, APOne important drawback of most of the currently used dendrimers for biomedical applications is their high stability under physiological conditions that can result in cytotoxicity or complications induced by the accumulation of non-degradable synthetic materials in the organism. Particularly in the gene therapy field, vector stability can further hinder the intracellular release of the nucleic acid from the dend...
Date: 2017
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Origin: Repositório Aberto da Universidade do Porto