56 documents found, page 1 of 6
Unveiling the antitumor mechanism of 7α-acetoxy-6β-hydroxyroyleanone from Plect...
Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Massenzio, Francesca; Spigarelli, RenatoGlioblastoma (GB) is the most aggressive and prevalent glioma within the central nervous system. Despite considerable efforts, GB continues to exhibit a dismal 5-year survival rate (∼6%). This is largely attributed to unfavorable prognosis and lack of viable treatment options. Therefore, novel therapies centered around plant-derived compounds emerge as a compelling avenue to enhance patient survival and well-be...
Editorial: III Bio.Natural-bioactive natural products research meeting: pharmac...
Rijo, Patrícia; Barros, Lillian; Efferth, ThomasThis Research Topic arises from the III Bio.Natural - Bioactive Natural Products Research Meeting, held on July 13–14, 2023, a forum dedicated to exploring the vast potential of natural products. Building on the success of the first two editions in 2019 and 2021 in Lisbon, this third edition continues to emphasize the significant contributions of natural products research, particularly their pharmacological pro...
Exploring the potential of Hermetia illucens larvae extracts: A promising appro...
Filipe, Márcia Santos; Cardoso, Rossana V.C.; Ayuso, Manuel; Murta, Daniel; Díaz-Lanza, Ana M.; Rosado, Catarina; Pires, Tânia C.S.P.Globally, the yearly disposal of 1.3 billion tonnes of food raises environmental and public health concerns. Black soldier fly (BSF) larvae present a sustainable solution, converting organic waste into nutrient-rich biomass. The extracted oil from BSF larvae, rich in fatty acids (FA), offers an eco-friendly alternative for the cosmetic industry. In this study, larvae sourced from a Portuguese company were fed o...
Biological activity of 6,7-Dehydroxyroyleanone and derivatives obtained from Pl...
Filipe, Márcia Santos; Domínguez-Martín, Eva M.; Pires, Tânia C.S.P.; Finimundy, Tiane C.; Melgar Castañeda, Bruno; Mandim, Filipa; Isca, Vera M. S.The Plectranthus genus (Lamiaceae) is known to be rich in abietane diterpenes. The bioactive 6,7-dehydroxyroyleanone (DHR, 1) was previously isolated from Plectranthus madagascariensis var. madagascariensis and var. aliciae. This study aimed to explore the occurrence of DHR, 1, in P. aliciae and the potential bioactivities of new semisynthetic derivatives from DHR, 1. Several extraction methods were evaluated, ...
Neocarya macrophylla (Chrysobalanaceae) : Review of taxonomy, ethnobotany, phyt...
Yusuf, Amina Jega; Abdullahi, Musa Ismail; Muhammad, Abubakar Alhaji; Ibrahim, Kasimu Ghandi; Wasagu, Hajara Adamu; Bräuning, Florencia Z.Neocarya macrophylla é usada tradicionalmente para fins alimentares, medicinais, espirituais e industriais. Também é utilizada como sabão, corante, cola, forragem, repelente de térmitas, lenha e como material estrutural. Existem poucos estudos sobre o conteúdo físico-químico, nutricional, fitoquímico e atividades farmacológicas que validem os benefícios de N. macrophylla para a humanidade como alimento, em cosm...
Topical application of a gel formulation containing Centauri honey enhances epi...
Lopes, Mariana Cariano; Rijo, Patrícia; Rodrigues, Luís MonteiroO mel é um dos mais antigos produtos naturais aplicados na pele humana. No entanto, as provas científicas de alguns dos seus impactos biológicos são recentes. O nosso estudo incide sobre o impacto do mel aplicado topicamente numa pele saudável. Para o efeito, foi concebido um estudo exploratório de 28 dias que envolveu oito participantes saudáveis de ambos os sexos, selecionados de acordo com critérios previame...
Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolys...
Bessa, Cláudia; Loureiro, Joana B.; Barros, Matilde; Isca, Vera M. S.; Sardão, Vilma A.; Oliveira, Paulo J.; Bernardino, Raquel L.Metabolic reprogramming is a central hub in tumor development and progression. Therefore, several efforts have been developed to find improved therapeutic approaches targeting cancer cell metabolism. Recently, we identified the 7a-acetoxy-6b-benzoyloxy-12-O-benzoylroyleanone (Roy- Bz) as a PKC -selective activator with potent anti-proliferative activity in colon cancer by stimulating a PKC -dependent mitochondr...
Coleon U, Isolated from Plectranthus mutabilis Codd., Decreases P-Glycoprotein ...
Jovanović Stojanov, Sofija; Ntungwe, Epole N.; Dinić, Jelena; Podolski-Renić, Ana; Pajović, Milica; Rijo, Patrícia; Pešić, MilicaMultidrug resistance in cancer is often mediated by P-glycoprotein. Natural compounds have been suggested as a fourth generation of P-glycoprotein inhibitors. Coleon U, isolated from Plectranthus mutabilis Codd., was reported to modulate P-glycoprotein activity but the underlying mechanism has not yet been revealed. Therefore, the effects of Coleon U on cell viability, proliferation, and cell death induction we...
Medicinal centauri honey: a promising ingredient?
Filipe, Márcia Santos; Pires, Tânia C.S.P.; Calhelha, Ricardo C.; Diaz-Lanza, Ana María; Vilas-Boas, Miguel; Falcão, Soraia; Rijo, PatríciaHoney is a natural product with antioxidant and antimicrobial properties, has been used as a medicinal substance for centuries. Thisnatural product is main- ly composed of a supersaturated solution of sugars, containing low water con- tent and trace amounts of bioactive compounds. The flower source, climate, geographical origin, harvesting process and storage conditions are factors that influence the compositio...
Centauri honey: a promising medicinal ingredient?
Filipe, Márcia Santos; Pires, Tânia C.S.P.; Calhelha, Ricardo C.; Diaz-Lanza, Ana María; Vilas-Boas, Miguel; Falcão, Soraia; Rijo, PatríciaHoney is a natural product that has been used over the centuries as a medicine due to its biological activities. Centauri Cave Nymph Honey is a Cave honey extracted from 2500 meters high altitude above sea level from a deep cave by professional speleologists and is located at Caucasus Mountains of Turkey. The Apis mellifera Caucasica bee colony is located 50 kilometers away from human residences, ensuring its i...