5 documents found, page 1 of 1
Infection with carcinogenic helminth parasites and its production of metabolite...
Gouveia, Maria João; Brindley, Paul J.; Rinaldi, Gabriel; Gärtner, Fátima; da Costa, José M.C.; Vale, NunoBackground: Infections classified as group 1 biological carcinogens include the helminthiases caused by Schistosoma haematobium and Opisthorchis viverrini. The molecular mediators underlying the infection with these parasites and cancer remain unclear. Although carcinogenesis is a multistep process, we have postulated that these parasites release metabolites including oxysterols and estrogen-like metabolites th...
Combination anthelmintic/antioxidant activity against Schistosoma Mansoni
Gouveia, Maria João; Brindley, Paul J.; Rinaldi, Gabriel; Gärtner, Fátima; da Costa, José Manuel Correia; Vale, NunoSchistosomiasis is a major neglected tropical disease. Treatment for schistosomiasis with praziquantel (PZQ), which is effective against the parasite, by itself is not capable to counteract infection-associated disease lesions including hepatic fibrosis. There is a pressing need for novel therapies. Due to their biological properties, antioxidant biomolecules might be useful in treating and reverting associated...
Differential responses of epithelial cells from urinary and biliary tract to eg...
Nacif-Pimenta, Rafael; da Silva Orfanó, Alessandra; Mosley, Ilana A.; Karinshak, Shannon E.; Ishida, Kenji; Mann, Victoria H.; Coelho, Paulo Marcos ZechChronic urogenital schistosomiasis can lead to squamous cell carcinoma of the bladder. The International Agency for Research on Cancer classifies the infection with S. haematobium as a group 1 carcinogen, a definitive cause of cancer. By contrast, hepatointestinal schistosomiasis due to the chronic infection with S. mansoni or S. japonicum associated with liver periportal fibrosis, does not apparently lead to m...
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder ...
Vale, Nuno; Gouveia, Maria J.; Rinaldi, Gabriel; Santos, Júlio; Santos, Lúcio Lara; Brindley, Paul J.; da Costa, José M. CorreiaUrogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced ...
Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Act...
Vale, Nuno; Gouveia, Maria João; Rinaldi, Gabriel; Brindley, Paul J.; Gärtner, Fátima; Correia da Costa, José M.Schistosomiasis, a major neglected tropical disease, affects more than 250 million people worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel (PZQ) for more than a generation. PZQ is the drug of choice for the treatment of schistosomiasis; it is effective against all major forms of schistosomiasis, although it is less active against juvenile than mature parasites. A pyrazino...