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Antioxidant Versus Cytotoxic Properties of Hydroxycinnamic Acid Derivatives - A...

Esteves, Mário; Siquet, Christophe; Gaspar, Alexandra; Rio, Vitor; Sousa, Joana B.; Reis, Salette; Marques, M. Paula M.; Borges, Fernanda

Trihydroxycinnamic derivatives were synthesized and evaluated for their antioxidant and cytotoxic activities. The ester derivatives exhibited a higher radical-scavenging activity, when liposomes were used as target systems, a fact which may be related to their lipophilicity and conformational preferences. These compounds were found to display significant growth inhibition and cytotoxic effects towards a human c...


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