7 documents found, page 1 of 1
Expression of microRNAs 16, 20a, 150 and 155 in anal squamous intraepithelial l...
Albuquerque, A; Fernandes, M; Stirrup, O; Teixeira, AL; Santos, J; Rodrigues, M; Rios, E; Macedo, G; Medeiros, RAnal squamous intraepithelial lesions (ASIL) or anal intraepithelial neoplasia (AIN) are precancerous lesions. microRNAs (miRNAs) have been implicated in cervical carcinogenesis, but have never been assessed in anal precancerous lesions. Our aim was to evaluate the expression of miR-16, miR-20a, miR-150 and miR-155 in several grades of ASIL obtained from high-risk patients, submitted to anal cancer screening fr...
The two faces of tumor-associated macrophages and their clinical significance i...
Pinto, ML; Rios, E; Durães, C; Ribeiro, R; Machado, JC; Mantovani, A; Barbosa, MA; Carneiro, F; Oliveira, MJMacrophages are one of the immune populations frequently found in colorectal tumors and high macrophage infiltration has been associated with both better and worst prognosis. Importantly, according to microenvironment stimuli, macrophages may adopt different polarization profiles, specifically the pro-inflammatory or M1 and the anti-inflammatory or M2, which display distinct functions. Therefore, concomitantly ...
NIS expression in thyroid tumors, relation with prognosis clinicopathological a...
Tavares, C; Coelho, MJ; Eloy, C; Melo, M; Rocha, AG; Pestana, A; Batista, R; Ferreira, LB; Rios, E; Selmi-Ruby, S; Cavadas, B; Pereira, LThyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS ...
OPNa overexpression is associated with matrix calcification in thyroid cancer c...
Ferreira, LB; Lima, RT; Bastos, A; Silva, AM; Tavares, C; Pestana, A; Rios, E; Eloy, C; Sobrinho-Simões, M; Gimba, E; Soares, POsteopontin (OPN) spliced variants (OPN-SV: OPNa, OPNb, and OPNc) are aberrantly expressed in tumors and frequently associated with cancer progression. This holds true for papillary thyroid carcinoma (PTC), which is the most common type of thyroid cancer (TC). PTC often presents with desmoplasia and dystrophic calcification, including psammoma bodies (PB). This work aimed to investigate total OPN (tOPN) and OPN...
mTOR pathway in papillary thyroid carcinoma: Different contributions of mTORC1 ...
Tavares, C; Eloy, C; Melo, M; Rocha, AG; Pestana, A; Batista, R; Ferreira, LB; Rios, E; Sobrinho-Simões, M; Soares, PThe mammalian target of rapamycin (mTOR) pathway is overactivated in thyroid cancer (TC). We previously demonstrated that phospho-mTOR expression is associated with tumor aggressiveness, therapy resistance, and lower mRNA expression of SLC5A5 in papillary thyroid carcinoma (PTC), while phospho-S6 (mTORC1 effector) expression was associated with less aggressive clinicopathological features. The distinct behavior...
Morphological features and mucin expression profile of breast carcinomas with s...
Bartosch, C; Mendes, N; Rios, E; Rodrigues, M; Eloy, C; Reis, CA; Amendoeira, ISignet-ring cells are relatively common in breast cancers but are frequently overlooked. Although previously defined as a subtype of mucin producing carcinomas, breast carcinomas with signet-ring cell (SRC) differentiation nowadays are not considered a distinct entity.The objective of the present study was to characterize the morphological features and mucin expression profile of breast carcinomas with SRC diff...
Vertebral osteoporotic fractures with height loss secondary to Cushing’s disease
Nogueira, C; Souto, SB; Rios, E; Pereira, J; Vinha, E; Freitas, P; Carvalho, D