10 documents found, page 1 of 1
Effects of exercise on depressive behavior and striatal levels of norepinephrin...
Daniele, Thiago Medeiros da Costa; Bruin, Pedro Felipe Carvalhedo de; Rios, Emiliano Ricardo Vasconcelos; Bruin, Veralice Meireles Sales deExercise is a promising adjunctive therapy for depressive behavior, sleep/wake abnormalities, cognition and motor dysfunction. Conversely, sleep deprivation impairs mood, cognition and functional performance. The objective of this study is to evaluate the effects of exercise on anxiety and depressive behavior and striatal levels of norepinephrine (NE), serotonin and its metabolites in mice submitted to 6 h of t...
Antioxidant properties of antiepileptic drugs levetiracetam and clonazepam in m...
Oliveira, Aline de Albuquerque; Linhares, Maria Isabel; Chaves Filho, Adriano José Maia; Rios, Emiliano Ricardo VasconcelosThis study aimed to investigate the in vitro antioxidant activity of the novel anticonvulsant levetiracetam and benzodiazepine clonazepam. To do this, the mice brain homogenates were incubated with levetiracetam (50, 100 or 200 g/ml) or clonazepam (50, 100 or 200 g/ml), and then, submitted to heating at 37°C for 1 h. Ascorbic acid (vitamin C, 200 g/ml) was used as reference antioxidant drug. The markers of o...
Efeito antinociceptivo do acetato de citronelila : estudo dos possíveis mecanis...
Rios, Emiliano Ricardo VasconcelosRIOS, Emiliano Ricardo Vasconcelos. Efeito antinociceptivo do acetato de citronelila : estudo dos possíveis mecanismos de ação. 2014. 115 f. Tese (Doutorado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2014.; This work shows for the first time the antinociceptive effect of the citronellyl acetate (CAT) and aimed to characterize the profile of effect and identify possible a...
Differential effects of paradoxical sleep deprivation on memory and oxidative s...
Lima, Alisson Menezes Araujo; Bruin, Veralice Meireles Sales de; Rios, Emiliano Ricardo Vasconcelos; Bruin, Pedro Felipe Carvalhedo deSleep has important functions for every organ in the body and sleep deprivation (SD) leads to disorders that cause irreparable damage. The aim of this study was to investigate behavioral and brain structural alterations in mice deprived of paradoxical sleep for 48 and 72 h. Working memory, aversive memory as well as levels of nitric oxide (NO) and thiobarbituric acid reactive substances (TBARS) in the hippocamp...
Synergistic effect of the L-tryptophan and kynurenic acid with dipyrone or para...
Rocha, Nayrton Flávio Moura; Rios, Emiliano Ricardo Vasconcelos; Carvalho, Alyne Mara Rodrigues; Freire, Leonardo Vasconcelos; Dias, Marília LeitePurpose: Our great interest in this work was study the synergism between L-tryptophan and dipyrone or paracetamol as well as the interaction of kynurenic acid (L-tryptophan metabolite) and these analgesics agents utilizing a robust methodology. Methods: We performed the writhing test induced by acetic acid in mice to evaluate the antinociceptive effect of the treatments isolated and combined (p.o. and i.p.). Do...
Evaluation of the anti-inflammatory activity of riparin II (O-methil- N-2-hidro...
Carvalho, Alyne Mara Rodrigues de; Rocha, Nayrton Flávio Moura; Vasconcelos, Leonardo Freire; Rios, Emiliano Ricardo Vasconcelos; Dias, Marília LeiteRiparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180–240 g) were treated with RipII by gavage at doses 25 or 50 mg/kg, before initiating the inflammatory responses. The tests used were paw edema induced by carrageenan, dextran, histamine or serotonin; peritoniti...
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate
Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Carvalho, Alyne Mara Rodrigues; Vasconcelos, Leonardo Freire; Dias, Marília LeiteBackground: Citronellyl acetate (CAT), a monoterpene product of the secondary metabolism of plants, has been shown in the literature to possess several different biological activities. However, no antinociceptive abilities have yet been discussed. Here, we used acute pain animal models to describe the antinociceptive action of CAT. Methods: The acetic acid-induced writhing test and the paw-licking test, in whic...
The effects of the brazilian ant Dinoponera quadriceps venom on chemically indu...
Lopes, Kamila Soares; Rios, Emiliano Ricardo Vasconcelos; Lima, Camila Nayane de Carvalho; Linhares, Maria Isabel; Torres, Alba Fabíola CostaArthropod venoms are potential sources of neuroactive substances, providing new tools for the design of drugs. The aim of this study was to evaluate the effects of Dinoponera quadriceps venom (DqV) on seizure models in mice induced by pentylenetetrazole (PTZ), pilocarpine, and strychnine. In the PTZ model, intraperitoneal treatment with DqV (0.5 mg/kg) increased the time until the first seizure and the percenta...
Antinociceptive activity of carvacrol (5-isopropyl-2- methylphenol) in mice
Melo, Francisca Helvira Cavalcante; Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Citó, Maria do Carmo de OliveiraObjectives Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol which is present in the essential oil of oregano and thyme.We have investigated the behavioural effects of carvacrol in animal models of pain, such as acetic acidinduced abdominal constriction, formalin and hot-plate tests in mice. The spontaneous motor activity of animals treated with carvacrol was investigated using open-field and rota...
Efeitos farmacológicos da Esculina em modelos animais de lesão gástrica e possí...
Rios, Emiliano Ricardo VasconcelosUlcer can be defined as a chronic inflammatory disease of the stomach and duodenum, which appears as a lesion in the digestive tract, which extends through the mucosa muscle or more deeply. The ulcer usually occurs because of an imbalance between protective and agrssive factors of the mucosa. Esculin (ESC) (6.7-Dihydroxycoumarin-6-O-Glucoside) was evaluated in models ethanol or indomethacin-induced gastric lesi...