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Peripheral antinociceptive action of mangiferin in mouse models of experimental...

Lopes, Synara C.; Silva, Ana Virgínia Lima da; Arruda, Bruno Rodrigues; Morais, Talita Cavalcante; Rios, Jeison Barros Rios

his study aimed to assess the possible systemic antinociceptive activity of mangiferin and to clarify the un- derlying mechanism, using the acute models of chemical (acetic acid, formalin, and capsaicin) and thermal (hot-plate and tail- fl ick) nociception in mice. Mangiferin at oral doses of 10 to 100 mg/kg evidenced signif- icant antinociception against chemogenic pain in the test models of acetic acid-induce...

Date: 2013 | Origin: Oasisbr

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