3 documents found, page 1 of 1
Increased ATP release and CD73-mediated adenosine A2A receptor activation media...
Augusto, Elisabete de Oliveira; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, MarcoExtracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR). Convulsive activity leads to increased ATP release, with the resulting morphological alterations being eliminated by A2AR blockade. However, it is not known i...
Clínica e Cirurgia em Animais de Companhia
Matos, MarcoEste estágio curricular foi realizado na CliniSPAD, no Funchal, ilha da Madeira, de outubro de 2014 a abril de 2015, sob a orientação da Dra. Raquel Fino. O relatório aqui apresentado divide-se em duas partes. Na primeira faz-se a descrição da casuística assistida e uma revisão bibliográfica dos casos com maior prevalência, seguido de um caso clínico-cirúrgico. Na segunda desenvolve-se o tema “Dermatite Alérgic...
Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocyt...
Moidunny, Shamsudheen; Matos, Marco; Wesseling, Evelyn; Banerjee, Santanu; Volsky, David J.; Cunha, Rodrigo A.; Agostinho, Paula; Boddeke, Hendrikus W.Background: Elevated levels of oncostatin M (OSM), an interleukin-6 cytokine family member, have been observed in HIV-1-associated neurocognitive disorders (HAND) and Alzheimer’s disease. However, the function of OSM in these disease conditions is unclear. Since deficient glutamate uptake by astrocytes is instrumental in HAND-associated neurotoxicity, we hypothesized that OSM impairs glutamate uptake in astrocy...