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Predictive factors of discordance between the instantaneous wave-free ratio and...

Dérimay, F; Johnson, N; Zimmermann, F; Adjedj, J; Witt, N; Hennigan, B; Koo, B; Barbato, E; Esposito, G; Trimarco, B; Rioufol, G; Baptista, SB

OBJECTIVES: To identify clinical, angiographic and hemodynamic predictors of discordance between instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR). BACKGROUND: The iFR was found to be non-inferior to the gold-standard FFR for guiding coronary revascularization, although it is discordant with FFR in 20% of cases. A better understanding of the causes of discordance may enhance application of t...


Impact of Routine Fractional Flow Reserve on Management Decision and 1-Year Cli...

Van Belle, E; Bravo Baptista, S; Raposo, L; Henderson, J; Rioufol, G; Santos, L; Pouillot, C; Ramos, R; Cuisset, T; Calé, R; Teiger, E; Jorge, E

Background: Fractional flow reserve (FFR) is not firmly established as a guide to treatment in patients with acute coronary syndromes (ACS). Primary goals were to evaluate the impact of integrating FFR on management decisions and on clinical outcome of patients with ACS undergoing coronary angiography, as compared with patients with stable coronary artery disease. Methods and results: R3F (French FFR Registry) ...


Continuum of Vasodilator Stress From Rest to Contrast Medium to Adenosine Hyper...

Johnson, N; Jeremias, A; Zimmermann, F; Adjedj, J; Witt, N; Hennigan, B; Koo, B; Maehara, A; Matsumura, M; Barbato, E; Esposito, G; Trimarco, B

OBJECTIVES: This study compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) ≤0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR). BACKGROUND: FFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved wit...


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