1 document found, page 1 of 1

A requirement for the abnormal spindle protein to organise microtubules of the ...

Drosophila abnormal spindle (asp) mutants exhibit a mitotic metaphase checkpoint arrest with abnormal spindle poles, which reflects a requirement for Asp for the integrity of microtubule organising centres. In male meiosis, the absence of a strong spindle integrity checkpoint enables asp mutant cells to proceed through telophase. However, the central spindle region is not correctly organised and cells frequentl...