10 documents found, page 1 of 1

Tuberculosis: integrated studies for a complex disease 2050

Tuberculosis (TB) has been a disease for centuries with various challenges [1]. Like other places where challenges and opportunities come together, TB challenges were the inspiration for the scientific community to mobilize different groups for the purpose of interest. For example, with the emergence of drug resistance, there has been a huge volume of research on the discovery of new medicines and drug delivery...

Functional and sequence-based metagenomics to uncover carbohydrate-degrading en...

The renewable, abundant, and low-cost nature of lignocellulosic biomass can play an important role in the sustainable production of bioenergy and several added-value bioproducts, thus providing alternative solutions to counteract the global energetic and industrial demands. The efficient conversion of lignocellulosic biomass greatly relies on the catalytic activity of carbohydrate-active enzymes (CAZymes). Find...

Evaluating data sharing of SARS-CoV-2 genomes for molecular epidemiology across...

Following the emergence of COVID-19 in December 2019, caused by the coronavirus SARS-CoV-2, the disease spread dramatically worldwide. The use of genomics to trace the dissemination of the virus and the identification of novel variants was essential in defining measures for containing the disease. We aim to evaluate the global effort to genomically characterize the circulating lineages of SARS-CoV-2, considerin...

Whole-genome sequencing and annotation of the yeast Clavispora santaluciae reve...

<i>Clavispora santaluciae</i> was recently described as a novel non-<i>Saccharomyces</i> yeast species, isolated from grapes of Azores vineyards, a Portuguese archipelago with particular environmental conditions, and from Italian grapes infected with <i>Drosophila suzukii</i>. In the present work, the genome of five <i>Clavispora santaluciae</i> strains was sequenced, assembled, and annotated for the first time...

Biomolecular insights into North African-related ancestry, mobility and diet in...

Historical records document medieval immigration from North Africa to Iberia to create Islamic al-Andalus. Here, we present a low-coverage genome of an eleventh century CE man buried in an Islamic necropolis in Segorbe, near Valencia, Spain. Uniparental lineages indicate North African ancestry, but at the autosomal level he displays a mosaic of North African and European-like ancestries, distinct from any prese...

Biotechnological Importance of Torulaspora delbrueckii: From the Obscurity to t...

<i>Torulaspora delbrueckii</i> has attracted interest in recent years, especially due to its biotechnological potential, arising from its flavor- and aroma-enhancing properties when used in wine, beer or bread dough fermentation, as well as from its remarkable resistance to osmotic and freezing stresses. In the present review, genomic, biochemical, and phenotypic features of <i>T. delbrueckii</i> are described,...

Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests c...

Association of leukotriene A4 hydrolase with tuberculosis susceptibility using ...

Leukotriene A4 hydrolase (LTA4H) is a key enzyme in the eicosanoid pathway. <i>lta4h</i> locus polymorphisms have previously been linked to tuberculosis (TB) susceptibility and disease outcome in a Vietnamese dataset, but further studies suggested that those results were poorly reproducible. We, therefore, compared the full set of variants (113 SNPs) within the gene in a Portuguese dataset of 112 TB patients an...

Genetic diversity and potential routes of transmission of Mycobacterium bovis i...

Bovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal products. In order to understand and quantify this risk and design intervention strategies, good epidemiological studies are needed. Such studies can include molecular typing of M. bovis isolates. The aim of this stud...

Mosaic maternal ancestry in the Great Lakes region of East Africa

The Great Lakes lie within a region of East Africa with very high human genetic diversity, home of many ethno-linguistic groups usually assumed to be the product of a small number of major dispersals. However, our knowledge of these dispersals relies primarily on the inferences of historical, linguistics and oral traditions, with attempts to match up the archaeological evidence where possible. This is an obviou...