15 documents found, page 1 of 2
Phylogeography of sub-Saharan mitochondrial lineages outside Africa highlights ...
Sá, Luísa; Almeida, Mafalda; Azonbakin, Simon; Matos, Erica; Franco-Duarte, Ricardo; Gómez-Carballa, Alberto; Salas, Antonio; Laleye, AnatóleDespite the importance of ancient DNA for understanding human prehistoric dispersals, poor survival means that data remain sparse for many areas in the tropics, including in Africa. In such instances, analysis of contemporary genomes remains invaluable. One promising approach is founder analysis, which identifies and dates migration events in non-recombining systems. However, it has yet to be fully exploited as...
Torulaspora delbrueckii phenotypic and metabolic profiling towards its biotechn...
Silva-Sousa, Flávia; Fernandes, Ticiana; Pereira, Fábio; Rodrigues, Diana; Rito, Teresa S; Camarasa, Carole; Franco-Duarte, Ricardo; Sousa, Maria JoãoWine is a particularly complex beverage resulting from the combination of several factors, with yeasts being highlighted due to their fundamental role in its development. For many years, non-<i>Saccharomyces</i> yeasts were believed to be sources of spoilage and contamination, but this idea was challenged, and many of these yeasts are starting to be explored for their beneficial input to wine character. Among t...
Improvement of Torulaspora delbrueckii genome annotation: towards the exploitat...
Santiago, Carolina; Rito, Teresa S; Vieira, Daniel; Fernandes, Ticiana; Pais, Célia; Sousa, Maria João; Soares, Pedro; Franco-Duarte, RicardoSaccharomyces cerevisiae is the most commonly used yeast in wine, beer, and bread fermentations. However, Torulaspora delbrueckii has attracted interest in recent years due to its properties, ranging from its ability to produce flavor- and aroma-enhanced wine to its ability to survive longer in frozen dough. In this work, publicly available genomes of T. delbrueckii were explored and their annotation was improv...
Phylogeography of 27,000 SARS-CoV-2 genomes: Europe as the major source of the ...
Rito, Teresa S; Richards, Martin B.; Pala, Maria; Correia-Neves, M; Soares, PedroThe novel coronavirus SARS-CoV-2 emerged from a zoonotic transmission in China towards the end of 2019, rapidly leading to a global pandemic on a scale not seen for a century. In order to cast fresh light on the spread of the virus and on the effectiveness of the containment measures adopted globally, we used 26,869 SARS-CoV-2 genomes to build a phylogeny with 20,247 mutation events and adopted a phylogeographi...
Evolutionary analysis of Mycobacterium bovis genotypes across Africa suggests c...
Inlamea, Osvaldo Frederico; Soares, Pedro; Ikuta, Cassia Yumi; Heinemann, Marcos Bryan; Achá, Sara Juma; Machado, Adelina; Ferreira Neto, José SoaresMycobacterium bovis is the pathogenic agent responsible for bovine tuberculosis (bTB), a zoonotic disease affecting mostly cattle, but also transmittable to humans and wildlife. Genetic studies on M. bovis allow to detect possible routes of bTB transmission and the identification of genetic reservoirs that may provide an essential framework for public health action. We used a database with 1235 M. bovis genotyp...
A dispersal of Homo sapiens from southern to eastern Africa immediately precede...
Rito, Teresa S; Vieira, Daniel; Silva, Marina; Conde-Sousa, Eduardo; Pereira, Luísa; Mellars, Paul; Richards, Martin B.; Soares, PedroAfrica was the birth-place of Homo sapiens and has the earliest evidence for symbolic behaviour and complex technologies. The best-attested early flowering of these distinctive features was in a glacial refuge zone on the southern coast 100-70 ka, with fewer indications in eastern Africa until after 70 ka. Yet it was eastern Africa, not the south, that witnessed the first major demographic expansion, ~70-60 ka,...
A nationwide study of multidrug-resistant tuberculosis in Portugal 2014-2017 us...
Oliveira, Olena Radomska; Gaio, Rita; Carvalho, Carlos; Correia-Neves, M; Duarte, Raquel; Rito, Teresa SIncreasing multidrug-resistant tuberculosis (MDR-TB) incidence is a major threat against TB eradication worldwide. We aim to conduct a detailed MDR-TB study in Portugal, an European country with endemic TB, combining genetic analysis and epidemiological data, in order to assess the efficiency of public health containment of MRD-TB in the country.
Untangling neolithic and bronze age mitochondrial lineages in South Asia
Silva, M.; Justeau, P; Rodrigues, S.; Oteo-Garcia, G.; Dulias, K.; Foody, G.; Fichera, A.; Yau, B.; Rito, Teresa S; Wilson, J. F.; Gandini, F.Two key moments shaped the extant South Asian gene pool within the last 10 thousand years (ka): the Neolithic period, with the advent of agriculture and the rise of the Harappan/Indus Valley Civilisation; and Late Bronze Age events that witnessed the abrupt fall of the Harappan Civilisation and the arrival of Indo-European speakers. This study focuses on the phylogeographic patterns of mitochondrial haplogroups...
Evidence of Austronesian genetic lineages in East Africa and South Arabia: comp...
Brucato, Nicolas; Fernandes, Veronica; Kusuma, Pradiptajati; Černý, Viktor; Mulligan, Connie J.; Soares, Pedro; Rito, Teresa S; Besse, CélineThe Austronesian dispersal across the Indonesian Ocean to Madagascar and the Comoros has been well documented, but in an unexplained anomaly, few to no traces have been found of the Austronesian expansion in East Africa or the Arabian Peninsula. To revisit this peculiarity, we surveyed the Western Indian Ocean rim populations to identify potential Austronesian genetic ancestry. We generated full mitochondrial D...
A complex scenario of tuberculosis transmission is revealed through genetic and...
Rito, Teresa S; Matos, Carlos; Carvalho, Carlos; Machado, Henrique Pedro Pereira Silva Amaral; Rodrigues, Gabriela; Oliveira, Olena; Ferreira, EduardaTuberculosis (TB) incidence is decreasing worldwide and eradication is becoming plausible. In low-incidence countries, intervention on migrant populations is considered one of the most important strategies for elimination. However, such measures are inappropriate in European areas where TB is largely endemic, such as Porto in Portugal. We aim to understand transmission chains in Porto through a genetic characte...