4 documents found, page 1 of 1
Author Correction: Efficient spatially targeted gene editing using a near-infra...
Rebelo, Catarina; Reis, Tiago; Guedes, Joana; Saraiva, Cláudia; Rodrigues, Artur Filipe; Simões, Susana; Bernardino, Liliana; Peça, João
Efficient spatially targeted gene editing using a near-infrared activatable pro...
Rebelo, Catarina; Reis, Tiago; Guedes, Joana; Saraiva, Cláudia; Rodrigues, Artur Filipe; Simões, Susana; Bernardino, Liliana; Peça, JoãoSpatial control of gene expression is critical to modulate cellular functions and deconstruct the function of individual genes in biological processes. Light-responsive gene-editing formulations have been recently developed; however, they have shown limited applicability in vivo due to poor tissue penetration, limited cellular transfection and the difficulty in evaluating the activity of the edited cells. Here,...
MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiatio...
Saraiva, Cláudia; Talhada, Daniela; Rai, Akhilesh; Ferreira, Raquel; Ferreira, Lino; Bernardino, Liliana; Ruscher, KarstenThere is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro ...
Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive ...
Santos, Tiago; Ferreira, Raquel; Quartin, Emanuel; Boto, Carlos; Saraiva, Cláudia; Bragança, José; Peça, João; Rodrigues, Cecília; Ferreira, LinoPreprint version; The authors would like to thank Ana Clara Cristóvão for her contributions. This work was funded by Fundação para a Ciência e Tecnologia (FCT), FEDER and COMPETE; (PTDC/SAU-NEU/104415/2008, FCOMP-01-0124-FEDER-041099, SFRH/BD/79526/2011), L'Oréal-UNESCO Portugal for Women in Science, Professor Francisco Pulido Valente Foundation, EC (ERC project no. 307384, “Nanotrigger”), COMPETE (Centro-07-ST...