31 documents found, page 1 of 4
Understanding inequality for European inclusion in SDG 10 of the 2030 United Na...
Nunes, N.; Mauritti, R.; Botelho, M.C.; Silva, S. F.; Cabrita, L.; Craveiro, D.Inequality is a major problem in modern times, with profound consequences for both human beings and the planet. As a continent with high standards of equality and quality of life, Europe benefits from more welfare institutions, redistributive systems, and inclusive development than the rest of the world, nevertheless it suffers from social malaise often caused by inequality. Even in Europe well-being is a far-o...
Imbalance of steroid hormones in hamsters infected with Schistosoma mansoni
Oliveira, K.C.; Cardoso, R.; Santos, A.C.D.; Fernandes, R.; Botelho, M.C.Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in t...
The use of helminths as anti-cancer agents
Botelho, M.C.; Fernandes, R.Recently, the hygiene hypothesis has been revisited to accommodate the connection between microorganisms and cancer. In a further pathogen-based observation, parasites and their extracts have been studied as antitumor inducers to substantiate the cancer hygiene hypothesis. Indeed, researchers observed the direct effect of molecules released by Echinococcus granulosus whose activity directly inhibits both cancer...
Os sindicatos no feminino: um ensaio sobre diferentes formas de visualização
Marques Alves, P.; Botelho, M.C.A representação visual de dados tem uma história secular, mas o debate sobre a visualização de informação ganhou nova dimensão com o conhecimento da perceção visual, com o uso de recursos informáticos e recentemente com a representação de big data. Este estudo propõe e discute representações visuais alternativas, em função dos objetivos e da análise estatística efetuada. Tem como objetivo a recolha, estrutura, ...
Angiogenesis in Schistosoma haematobium-associated urinary bladder cancer
Dematei, A.; Fernandes, R.; Soares, R.; Alves, H.; Richter, J.; Botelho, M.C.Schistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. During infection, eggs are deposited in the bladder causing an intense inflammatory reaction. Angiogenesis is defined as the formation of new blood ve...
Expression of angiogenic and inflammation markers in murine schistosomiasis man...
Dematei, A.; Fernandes, R.; Soares, R.; Alves, H.; Richter, J.; Botelho, M.C.Aim: to study angiogenesis in the livers of mice infected with S. mansoni.
Steroid hormones in murine schistosomiasis mansoni
Oliveira, K.C.; Cardoso, R.; Dos Santos, A.C.; Alves, H.; Richter, J.; Botelho, M.C.Schistosomiasis is a neglected tropical disease, endemic in 76 countries, that afflicts more than 240 million people. The impact of schistosomiasis on infertility may be underestimated according to recent literature. Extracts of Schistosoma (S.) haematobium include estrogen-like metabolites termed catechol-estrogens that down regulate estrogen receptors alpha and beta in estrogen responsive cells. In addition, ...
Estrogen catechols detection as biomarkers in schistosomiasis induced cancer an...
Botelho, M.C.; Alves, H.; Richter, J.Urogenital schistosomiasis is a chronic infection caused by the human blood fluke Schistosoma haematobium. Schistosomiasis haematobium is a known risk factor for cancer leading to squamous cell carcinoma of the urinary bladder (SCC). This is a neglected tropical disease endemic in many countries of Africa and the Middle East. Schistosome eggs produce catechol-estrogens. These molecules are metabolized to active...
Estrogen Metabolism-Associated CYP2D6 and IL6-174G/C Polymorphisms in Schistoso...
Cardoso, R.; Lacerda, P.C.; Costa, P.P.; Machado, A.; Carvalho, A.; Bordalo, A.; Fernandes, R.; Soares, R.; Richter, J.; Alves, H.; Botelho, M.C.Schistosoma haematobium is a human blood fluke causing a chronic infection called urogenital schistosomiasis. Squamous cell carcinoma of the urinary bladder (SCC) constitutes chronic sequelae of this infection, and S. haematobium infection is accounted as a risk factor for this type of cancer. This infection is considered a neglected tropical disease and is endemic in numerous countries in Africa and the Middle...
Anti-cancer potential of Fasciola hepatica extracts
Ferreira, S.; Fernandes, R.; Alves, H.; Richter, J.; Botelho, M.C.Fascioliasis is a food borne disease caused by infection with a liver fluke termed Fasciola (F.) hepatica. Fascioliasis, as a neglected tropical disease, commonly affects poor people from developing countries. It has been estimated that at least 2.6 million people are infected with fascioliasis worldwide. According to the International Agency for Research on Cancer, two other liver flukes Opistorchis viverrini ...