4 documents found, page 1 of 1
Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses
Vasili, Eftychia; König, Annekatrin; Al-Azzani, Mohammed; Bosbach, Clara; Gatzemeier, Luisa Maria; Thom, Searlait; Chegão, Ana; Vicente Miranda, HugoPublisher Copyright: © The Author(s) 2025.; The risk of developing Parkinson’s disease (PD) is elevated in individuals with type 2 diabetes (T2DM), but the molecular pathways underlying this link remain unclear. Glycation, a non-enzymatic modification of lysine and arginine residues by reducing sugars or reactive dicarbonyls, may disrupt proteostasis and trigger pathology. Here, we investigated how methylglyoxa...
Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease...
Chegão, Ana; Guarda, Mariana; Alexandre, Bruno M.; Shvachiy, Liana; Temido Ferreira, Mariana; Marques-Morgado, Inês; Fernandes Gomes, BárbaraAlpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson's disease (PD). Interestingly, a common molecular alteration among these disorders is the age-associated increase in protein glycation. ...
Underlying role of glycation in the pathogenesis of Parkinson’s disease
Chegão, AnaParkinson’s disease (PD) is the most common movement disorder and the second most common neurodegenerative disorder, affecting 7 to 10 million people worldwide and is an age-related disease. PD is characterized by a progressive motor decline that includes bradykinesia and tremor, and by non-motor features such as mood and cognitive changes and belongs to a wide group of neurodegenerative diseases known as synuc...
Posttranslational modifications of blood-derived alpha-synuclein as biochemical...
Vicente Miranda, Hugo; Cassio, Rafaela; Correia Guedes, Leonor; Gomes, Marcos António; Chegão, Ana; Miranda, Elisa; Soares, Tiago; Coelho, MiguelParkinson's disease (PD) is a progressive neurodegenerative disorder known for the typical motor features associated. Pathologically, it is characterized by the intracellular accumulation of alpha-synuclein (aSyn) in Lewy bodies and Lewy neurites. Currently, there are no established biochemical markers for diagnosing or for following disease progression, a major limitation for the clinical practice. Posttransla...