3 documents found, page 1 of 1
Translating Results From the Cardiovascular Outcomes Trials with Glucagon-Like ...
Janez, A; Muzurovic, E; Stoian, A; Haluzik, M; Guja, C; Czupryniak, L; Duvnjak, L; Lalic, N; Tankova, T; Bogdanski, P; Papanas, N; Silva Nunes, JGlucagon-like peptide-1 (GLP-1) receptor agonists mimic the action of the endogenous GLP-1 incretin hormone, improving glycaemic control in type 2 diabetes mellitus (T2DM) by increasing insulin secretion and decreasing glucagon secretion in a glucose-dependent manner. However, as cardiovascular (CV) morbidity and mortality is common in patients with T2DM, several trials with the use of GLP-1 receptor agonists (...
The Role of the Metabolome and Non-Coding RNA on Pheochromocytomas and Paragang...
Bouça, B; Bogalho, P; Rizzo, M; Silva-Nunes, JPheochromocytoma and paragangliomas (PPGL) are rare neuroendocrine tumors. In some patients they exhibit malignant behavior characterized by the presence of metastases, limiting treatment options and survival rates. Therapeutic options are limited to surgery, localized radiotherapy, and a few systemic therapies. However, in several recent studies, non-coding RNA molecules are gaining increasing attention as mar...
Absolute Hyperglycemia versus Stress Hyperglycemia Ratio for the Prognosis of H...
Matias, AA; Manique, I; Sabino, T; Rego, T; Mihon, C; Panarra, A; Rizzo, M; Silva-Nunes, JDiabetes is a risk factor for greater severity of coronavirus disease 2019 (COVID-19). The stress hyperglycemia ratio (SHR) is an independent predictor of critical illness, and it is reported to have a stronger association than absolute hyperglycemia. The aim of this study was to assess the relationship of absolute hyperglycemia and SHR with the severity of COVID-19, since there are no studies investigating SHR...