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Climate change, human health, and resilience in the Holocene

Robbins Schug, Gwen; Buikstra, Jane E.; DeWitte, Sharon N.; Baker, Brenda J.; Berger, Elizabeth; Buzon, Michele R.; Davies-Barrett, Anna M.

Climate change is an indisputable threat to human health, especially for societies already confronted with rising social inequality, political and economic uncertainty, and a cascade of concurrent environmental challenges. Archaeological data about past climate and environment provide an important source of evidence about the potential challenges humans face and the long-term outcomes of alternative short-term ...


Mycobacterium leprae diversity and population dynamics in medieval Europe from ...

Pfrengle, Saskia; Neukamm, Judith; Guellil, Meriam; Keller, Marcel; Molak, Martyna; Avanzi, Charlotte; Kushniarevich, Alena; Montes, Núria

Background: Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significant...


Mycobacterium leprae diversity and population dynamics in medieval Europe from ...

Pfrengle, Saskia; Neukamm, Judith; Guellil, Meriam; Keller, Marcel; Molak, Martyna; Avanzi, Charlotte; Kushniarevich, Alena; Montes, Núria

Background: Hansen’s disease (leprosy), widespread in medieval Europe, is today mainly prevalent in tropical and subtropical regions with around 200,000 new cases reported annually. Despite its long history and appearance in historical records, its origins and past dissemination patterns are still widely unknown. Applying ancient DNA approaches to its major causative agent, Mycobacterium leprae, can significant...


Mycocerosic acid biomarkers for the diagnosis of tuberculosis in the Coimbra Sk...

Redman, Janet E.; Shaw, Matthew J.; Mallet, Anthony I.; Santos, Ana Luísa; Roberts, Charlotte A.; Gernaey, Angela M.; Minnikin, David E.

Tuberculosis has been a scourge of humans over many millennia, but questions remain regarding its evolution and epidemiology. Fossil biomarkers, such as DNA and long-chain mycolic acids, can be detected in ancient skeletal and other materials. The phthiocerol dimycocerosate waxes are also robust biomarkers for tuberculosis and sensitive methods are available for the detection of their mycocerosic acid component...


A picture of tuberculosis in young Portuguese people in the early 20th century:...

Santos, Ana Luísa; Roberts, Charlotte A.

The aim of this study was to examine the evidence, and consider the differential diagnosis, for tuberculosis (TB) in juvenile individuals from early 20th century documented skeletons. There are 66 male and female juvenile individuals in the Coimbra Identified Skeletal Collection (CISC) with an age at death ranging from 7-21 years. The individuals died between 1904-1936 in different areas of Coimbra, Portugal. E...


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