2 documents found, page 1 of 1
Decreasing the time to achieve therapeutic vancomycin concentrations in critica...
Baptista, JP; Roberts, JA; Sousa, E; Freitas, R; Deveza, N; Pimentel, JINTRODUCTION: Achievement of optimal vancomycin exposure is crucial to improve the management of patients with life-threatening infections caused by susceptible Gram-positive bacteria and is of particular concern in patients with augmented renal clearance (ARC). The aim of this study was to develop a dosing nomogram for the administration of vancomycin by continuous infusion for the first 24 hours of therapy ba...
A comparison of estimates of glomerular filtration in critically ill patients w...
Baptista, JP; Udy, AA; Sousa, E; Pimentel, J; Wang, L; Roberts, JA; Lipman, JINTRODUCTION: Increasingly, derived estimates of glomerular filtration, such as the modification of diet in renal disease (MDRD) equation and Cockcroft-Gault (CG) formula are being employed in the intensive care unit (ICU). To date, these estimates have not been rigorously validated in those with augmented clearances, resulting in potentially inaccurate drug prescription. METHODS: Post-hoc analysis of prospecti...