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Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysi...
Robinson, L; Roccaldo, R; Rodrigues, D; Rodriguez Perez, MdC; Rodríguez Villamizar, LA; Rodríguez, AY; Roggenbuck, U; Rohloff, P; Rohner, FBackground: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods: We used data from 3663 population-based studies with 222 million participants that...
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis ...
Sant'Anna, R; Gallego, P; Robinson, L; Pereira-Henriques, A; Ferreira, N; Pinheiro, F; Esperante, S; Pallares, I; Huertas, O; Almeida, M; Reixach, NTransthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a potent TTR aggregation inhibitor. Tolcapone binds specifically to TTR in human plasma, stabilizes...